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Brain Injury : Molecular and Cellular Biology of Critical Care Medicine, 2 - Robert S.B. Clark

Brain Injury

Molecular and Cellular Biology of Critical Care Medicine, 2

By: Robert S.B. Clark (Editor), Patrick Kochanek (Editor)

Hardcover

Published: 31st October 2001
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  • Paperback View Product Published: 5th November 2012
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Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury.
This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.

Foreword
Preface
Contributors
Excitotoxic Damage in Traumatic Brain Injury
The Multifaceted Role of Adenosine in Experimental and Clinical Traumatic Brain Injury
Preconditioning
Molecular and Cellular Mechanisms of Traumatic Cerebral Vascular Injury
Inflammatory Response to Brain Injury
Free Radicals and Acute Brain Injury: Mechanisms of Oxidative Stress and Therapeutic Potentials
Mitochondria in Acute Brain Injury
Cell Signaling: Serine/Threonine Protein Kinases and Traumatic Brain Injury
Death Receptors in Acute Brain Injury
Apoptosis
Ischemia-Induced Ionic Mechanisms of Injury in the Developing Brain
Neurocytoskeletal Changes Following Traumatic Brain Injury
Neurotransmitter and Growth Factor Alterations in Functional Deficits and Recovery Following Traumatic Brain Injury
Reproductive Hormones as Neuroprotectants in Brain Injury
Role of Genetic Background: Influence of Apolipoprotein E Genotype in Alzheimer's Disease and After Head Injury
Anesthetics and the Injured Brain
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780792375326
ISBN-10: 0792375327
Series: Molecular and Cellular Biology of Critical Care Medicine, 2
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 384
Published: 31st October 2001
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.88  x 2.54
Weight (kg): 0.66