This Clinic in Developmental Medicine describes a meticulous survey of germinal matrix/intraventricular hemorrhage in preterm infants, which took place in three New Jersey counties between 1984 and 1987. The babies under study weighed 501-2000g at their birth. They were studied prospectively with cranial ultrasound; the findings were correlated with very detailed pathological examination of the brains of those who died, and with later outcome in the survivors. The numbers studied in this population-based sample were large enough both to test and to generate hypotheses about the causes and consequences of hemorrhage.
1. The central New Jersey neonatal brain hemorrhage study: an overview.
2. Neuropathologic methods.
3. Ultrasonographic methods.
4. The pathology of germinal matrix/intraventricular hemorrhage: a review.
5. Germinal matrix and intraventricular bleeding: location, extent, ultrasound imaging.
6. White matter damage: terminology, typology, pathogenesis.
7. The varieties of leukomalacia.
8. Subarachnoid hemorrhage.
9. Associated lesions: cerebellar hemorrhage, subicular necrosis, thalamic necrosis.
10. The prognosis of brain damage in preterm infants.