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Brain Damage, Brain Repair - James Fawcett

Brain Damage, Brain Repair

By: James Fawcett, Anne Rosser (Editor), Stephen Dunnett (Editor)

Hardcover

Published: 1st May 2001
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Many neurological conditions are caused by damage to neurons and glial cells. For most of these diseases there are at present no effective treatments to minimise the extent of neuronal and glial loss, and no effective way of replacing what has been lost. This picture is rapidly changing. Developments in basic neuroscience have produced various potential therapies that can protect neurons and glia following traumatic, anoxic, infectious and immunological damage. The old doctrine that axons cannot be made to regenerate, and dead neurons cannot be replaced is no longer tenable, and a wide variety of reconstructive techniques for the nervous system are under development. These and other basic science discoveries will progress into clinical practice, and lead to a revolution in neurology and neurosurgery. This book describes the various conditions that lead to damage to the nervous system, and the ways in which they may be ameliorated. It covers the burgeoning science of reconstruction of the nervous system, through neuronal, glial and stem cell transplantation, axon regeneration, remyelination, plasticity and pharmacological interventions. The clinical conditions to which these treatments will be applied and their assessment are described. This is the first book to cover this enormous and expanding field of neuroscience and neurology. It will be useful to students and scientists working in the field of nervous system damage and reconstruction, and also to clinicians who wish to look forward to the developments which will shape the future of their practice

"Brain Damage, Brain Repair is an excellent and authoritative source book on what, for most people, is the most important question about the nervous system--how to repair the damage inflicted by the ever more violent ways of peace and war and the depredations of age."--Nature "Brain Damage, Brain Repair is an excellent and authoritative source book on what, for most people, is the most important question about the nervous system--how to repair the damage inflicted by the ever more violent ways of peace and war and the depredations of age."--Nature "Brain Damage, Brain Repair is an excellent and authoritative source book on what, for most people, is the most important question about the nervous system--how to repair the damage inflicted by the ever more violent ways of peace and war and the depredations of age."--Nature "Brain Damage, Brain Repair is an excellent and authoritative source book on what, for most people, is the most important question about the nervous system--how to repair the damage inflicted by the ever more violent ways of peace and war and the depredations of age."--Nature

Section I: Mechanisms of Brain Damage 1: Death and Survival in the Nervous System 2: Axotomy and mechanical damage 3: Metabolic damage 4: Inflammation and demyelination (with Neil Scolding) 5: Infection (with Roger Barker) 6: Neurodegenerative disease (with Harry Baker) Section II: Damage Limitation 7: Neuroprotection 8: Steroids (Joe Herbert) 9: Growth factors 10: Control of inflammation Section III: Intrinsic mechanisms of recovery 11: Peripheral Nerve Regeneration 12: Failure of CNS regeneration 13: Anatomical plasticity 14: Biochemical plasticity 15: Remyelination (Robin Franklin) Section IV: Clinical Assessment of Brain Damage 16: Coma 17: Motor, sensory and autonomic failure (with Charlotte Behan) 18: Cognition (with Andrew Lawrence and B J Sahakian) 19: Neuropsychiatry (with German Berrios and Eugene Paykel) Section V: Pharmacology and Rehabilitation 20: Pharmacological Management 21: Neuropsychological rehabilitation (Ian Robertson and Barbara Wilson) Section VI: Structural Repair 22: Axon Regeneration in the CNS 23: Primary neuronal grafts 24: Glial grafts (Robin Franklin) 25: Stem cells 26: Gene therapy (with Stacey Efsthathiou) Appendix

ISBN: 9780198523383
ISBN-10: 0198523386
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 482
Published: 1st May 2001
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 25.3 x 19.5  x 3.1
Weight (kg): 1.22