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Brain Damage and Repair : From Molecular Research to Clinical Therapy - T. Herdegen

Brain Damage and Repair

From Molecular Research to Clinical Therapy

By: T. Herdegen (Editor), J. Delgado-Garcia (Editor)

Hardcover Published: 14th May 2007
ISBN: 9781402018923
Number Of Pages: 721

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Brain Damage and Repair aims to attract the interest of neuroscientists and clinical neurologists by building a novel bridge from molecular research to clinical therapy. This novel approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration. Comprehensive chapters on neurological diseases, such as M. Alzheimer, M. Parkinson, ALS, stroke or trauma, take this knowledge, apply it at the clinical level to provide a basis for novel therapeutic strategies. Brain Damage and Repair is completed with chapters on imaging techniques, viral gene transfer or legal international handling of stem cell transfer and patents of DNA/proteins.

Accompanying Words
Preface
Members of the Management Committee
The Vulnerable Neuron or Why Neurons Die
The aging brain - the burden of life
Gene expression and its regulation in neurons
Morphological peculiarities of the neuron
Synaptic plasticity: hyperexcitability and synaptic silencing
The axonal burden
The self-destruction of neurons - physiological and pathophysiological decisions for the functional integrity
The organelles I: Mitochondrial failure
The organelles II: Endoplasmic reticulum and its overload
Transcriptional dysfunctions as pathogenic mechanism of neurodegenerative diseases
Formation of radicals
The Extraneuronal Matrix - Sites of Multiple Degenerative Processes
Axon guidance and repulsion. The molecular code of social life in the brain
Microglia and the cerebral defence system
Generation and differentiation of astrocytes during central nervous system development and injury
Oligodendrocytes in health and disease
The myelin glial cell of the peripheral nervous system: The Schwann cell
The Muller glia: role in neuroprotection
The Brave Neuron - Self-Protection, Plasticity and Restoration
Neural plasticity and regeneration: myths and expectations
Neuronal protection against oxidative damage
Functional recovery in the peripheral and central nervous system after injury
Neural plasticity and the cell biology of learning
Neural plasticity and central nervous system lesion repair
Regulation of the intrinsic growth properties in mammalian neurons
Glutamate, calcium and neurodegenerative disease: impact of cytosolic calcium buffers and their potential role for neuroprotective strategies
Postnatal neurogenesis and neuronal regeneration
Migration disorders and epilepsy
Therapeutic Principles
Invasive strategies as therapeutic approaches for central nervous system diseases
General aspects of neuropharmacology in relation to brain repair following trauma
Stem cells and nervous tissue engineering
Cell transplants and artificial guides for nerve repair
Modern late neurologic rehabilitation: neuroscience and motivating functional rehabilitation
Viral gene delivery
The Neurodegenerative Disorders: Molecular Pathogenesis and Treatment
General remarks on the bridging between basic research and clinics
Mechanical lesions of the peripheral nervous system
Stroke and ischemic insults
Parkinson's disease I: Degeneration and dysfunction of dopaminergic neurons
Parkinson's disease II: Replacement of dopamine and restoration of striatal function
Alzheimer's disease
Amyotrophic lateral sclerosis and related disorders
Pharmacological strategies for neurodegeneration and overview of clinical trials
Monitoring brain dysfunction through imaging techniques
Functional assessment of human brain with non-invasive electrophysiological methods
Legal implications o
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9781402018923
ISBN-10: 1402018924
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 721
Published: 14th May 2007
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 3.56
Weight (kg): 1.46