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Bortezomib in the Treatment of Multiple Myeloma : Milestones in Drug Therapy - Kenneth C. Anderson

Bortezomib in the Treatment of Multiple Myeloma

Milestones in Drug Therapy

By: Kenneth C. Anderson (Editor), Paul G. Richardson (Editor), Irene Ghobrial (Editor)

Hardcover Published: 30th December 2010
ISBN: 9783764389475
Number Of Pages: 180

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Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.

Bortezomib's Scientific Origins and Its Tortuous Path to the Clinicp. 1
Preclinical Activities of Bortezomib in MM, the Bone Marrow Microenvironment and Pharmacogenomicsp. 29
Bortezomib and Osteoclasts and Osteoblastsp. 43
Bortezomib in the Upfront Treatment of Multiple Myelomap. 53
The Use of Bortezomib in Autologous Transplantation for Multiple Myelomap. 69
Bortezomib in Relapsed and Relapsed/Refractory Multiple Myelomap. 79
Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma: Principles of Identification and Managementp. 95
Bortezomib in Mantle Cell Lymphomap. 107
Bortezomib in Waldenstrom's Macroglobulinemiap. 123
Bortezomib in Systemic Light-Chain Amyloidosisp. 135
Second-Generation Proteasome Inhibitorsp. 149
Indexp. 177
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9783764389475
ISBN-10: 3764389478
Series: Milestones in Drug Therapy
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 180
Published: 30th December 2010
Publisher: Birkhauser Verlag AG
Country of Publication: CH
Dimensions (cm): 23.5 x 15.5  x 1.27
Weight (kg): 0.44