Boron Neutron Capture Therapy : Toward Clinical Trials of Glioma Treatment

By: Detlef Gabel (Editor), Renate Alberts (Adapted By), Raymond Moss (Editor)

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Two dozen substantial papers from a workshop in Petten, the Netherlands, September 1991, present a snapshot of the use of boron neutron capture therapy for the treatment of cancer, at the moment when the results of the first clinical trials on humans were just available, and several countries were c

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Non-Fiction Science Chemistry Medicine Clinical & Internal Medicine Neurology & Clinical Neurophysiology Diseases & Disorders Oncology Infectious & Contagious Diseases Other Branches of Medicine Pharmacology Medical Imaging

Opening Speech	p. 1
Welcome Address	p. 5
Safety and Efficacy in Boron Neutron Capture Therapy	p. 7
Some Aspects of BNCT Research at the Brookhaven National Laboratory	p. 15
INEL BNCT Program Directions With Respect to Clinical Trials of BNCT	p. 23
The Department of Energy Research Program in Boron Neutron Capture Therapy	p. 29
Current Overview on the Approach of Clinical Trials at Petten	p. 33
Review of the Physics Calculations Performed for the BNCT Facility at the HFR Petten	p. 47
From Filter Installation to Beam Characterization	p. 59
Neutron Spectrometry Measurements of the Petten HFR, HB11 Neutron Beam	p. 79
A Semi-Empirical Method of Treatment Planning for Boron Neutron Capture Therapy	p. 93
Present Status of the Three-Dimensional Treatment Planning Methodologies for the Petten BNCT Facility	p. 101
A Phase 1 Biodistribution Study of p-Boronophenylalanine	p. 111
RBE in Normal Tissue Studies	p. 123
Treatment Planning and Optimization for Pion Therapy	p. 129
Dose Calculations Based on Image Reconstructions	p. 143
Borocaptate Sodium (BSH) Pharmacokinetics in Glioma Patients	p. 155
BSH in Patients With Malignant Glioma: Distribution in Tissues, Comparison Between BSH Concentration and Histology	p. 163
Macroscopic and Microscopic Biodistribution of BSH in a Rat Glioma Model	p. 175
Healthy Tissue Tolerance Studies for BNCT at the High Flux Reactor in Petten - First Results	p. 179
Cellular Pharmacokinetics of BNCT Compounds and Their Cellular Localization With EELS/ESI	p. 189
Large Animal Model Studies of Normal Tissue Tolerance Using an Epithermal Neutron Beam and Borocaptate Sodium	p. 197
Proposal for Patient Selection Criteria and Follow-Up for BNCT in Patients With Supratentorial Malignant Gliomas	p. 211
A Proposal for Phase I Clinical Trials of Glioma Patients	p. 219
Approaches to the Design and Evaluation of Compounds for BNCT	p. 223
The Implementation Strategy for BNCT Trials in Australia	p. 231
Round Table Discussion: Approach to Clinical Trials of Glioma	p. 243
Author Index	p. 265
Participants	p. 267
Subject Index	p. 275
Table of Contents provided by Blackwell. All Rights Reserved.

Boron Neutron Capture Therapy : Toward Clinical Trials of Glioma Treatment

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