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Bone Metastasis and Molecular Mechanisms : Pathophysiology - Gurmit Singh

Bone Metastasis and Molecular Mechanisms

Pathophysiology

By: Gurmit Singh (Editor), William Orr (Editor)

Hardcover Published: 31st March 2004
ISBN: 9781402019845
Number Of Pages: 308

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Patients with advanced Breast or Prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to the quality of life for patients with breast and prostate cancer.
Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.
The book provides an overview of molecular factors that offer targets and avenues for therapeutic strategies.

List of Contributors
Preface
Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model
Quantitation of Bone Metastasis in Experimental Systems
Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease
Clinical Modalities for the Diagnosis and Characterization and Detection of Bone Metastases
Metastasis in the Bone Marrow Microenviroment
The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis
The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells
Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking
Prostate Cancer: Models for Developing Novel Therapeutic Approaches
Potential Therapeutic Targets for Bone Metastasis
Opg Rank and Rankl in Bone Metastasis and Cancer-Associated Osteolysis
Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer
The Role of Bisphosphonates in Bone Metastasis
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9781402019845
ISBN-10: 140201984X
Series: Cancer Metastasis - Biology and Treatment
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 308
Published: 31st March 2004
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 29.7 x 21.0  x 1.91
Weight (kg): 1.4