Blood Brain Barrier : Drug Delivery and Brain Pathology - David Kobiler

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Blood Brain Barrier

Drug Delivery and Brain Pathology

By: David Kobiler (Editor), Shlomo Lustig (Editor), Shlomo Shapira (Editor)

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Hardcover | 28 February 2002

At a Glance

Hardcover
448 Pages

Dimensions(cm)
25.4 x 17.78 x 2.54

Hardcover

$139.00

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These proceedings review and discuss the different aspects of the biology of the Blood-Brain Barrier (BBB) and its involvement in the pathogenesis of brain disorders.
The BBB, formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, serves as a controlled functional gate to CNS. In vitro and in vivo models have been established to study the cellular and molecular interaction within the BBB and between the BBB and the neural cells.
The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the CNS, including neoplasia, ischemia, trauma, inflammation and bacterial and viral infections.
Two approaches to drug delivery across the BBB have been pursued, based on either modulation of the permeability of the barrier or by conjugation of the drug to substrates of the active transport systems of the BBB.

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Non-Fiction Medicine Nursing & Ancillary Services Pharmacy & Dispensing Clinical & Internal Medicine Neurology & Clinical Neurophysiology Diseases & Disorders Immunology Other Branches of Medicine Pathology Pharmacology Science

Biology, Life Sciences Life Sciences in General Molecular Biology Veterinary Medicine

Overview of the Structure and Function of the Blood-Brain Barrier in vivo	p. 1
Expression and Modulation of Blood-Brain Monocarboxylate Transporters	p. 9
Neuroprotective and Detoxifying Mechanisms at the Blood-Brain Interfaces	p. 19
Measurement and Prediction of Blood-Brain Barrier Permeability: In vivo, in silico and in vitro approaches	p. 27
Recent Advances in the Development of Cell Culture Models for the Blood-Brain and Blood-CSF-Barrier	p. 45
Gene Expression Changes and Progression to a BBB Phenotype in a Dynamic Model of the BBB	p. 63
Novel Endothelial-Mediated Responses Associated with Micro-Circulation and BBB Function	p. 71
Modulators of Blood-Brain Barrier (BBB) Permeability: In Vitro and In Vivo Drug Transport to the Brain	p. 83
Controlled Modulation of the Blood-Brain and Blood-Tumor Barrier Using Novel Lipid Mimetic Compounds	p. 99
Carbon Dioxide Gas as an Angiographic Contrast Agent in the Cerebral Circulation	p. 113
Diffusion MRI and Q-Space Diffusion MRI: From Cerebral Ischemia to Multiple Sclerosis and Beyond	p. 123
Brain Iron Uptake and Transport in Animal Model of Iron Deficiency, Tardive Dyskinesia and Neurodegenerative Diseases	p. 147
Stress, Pyridostigmine and the Blood-Brain Barrier	p. 157
Transcytosis and Signalling of Pneumococci at the Blood-Brain Barrier	p. 169
Entry of Viruses into the Central Nervous System	p. 177
An Animal Model for the Study of BBB Modulators	p. 191
Physiological Pathways Responsible for the Breakdown of the Blood-Brain Barrier During Viral Encephalitis	p. 205
Gene Transfer to the Salivary Glands: Application in Gene Therapy	p. 217
The Effect of Hyperosmotic Blood-Brain Barrier Disruption on Experimental Autoimmune Encephalomyelitis	p. 227
Direct In Vivo Evidence for [alpha]4-Integrin Mediated Interaction of Encephalitogenic T Cells with Endothelial VCAM-1 in the Spinal Cord White Matter Using Intravital Fluorescence Videomicroscopy	p. 233
The Blood-Brain Barrier in Immune Mediated Diseases of the Central Nervous System	p. 243
Strategies for Increasing Drug Delivery to the Brain: Lessons Derived from Treatment of Brain Tumors	p. 251
Intraarterial Therapy With or Without Radiation Therapy for Patients with Brain Tumors	p. 273
Optimizing Drugs for Brain Action	p. 281
The Role of Plasma Protein Binding in Drug Delivery to Brain	p. 311
Issues Related to Intranasal Delivery of Neuropeptides to Temporal Lobe Targets	p. 323
Synthesis of Poly(Carboxyphenoxypropane-Sebacic Anhydride) for the Delivery of Drugs to the Brain	p. 351
Intranasal Delivery of Bioactive Peptides or Peptide Analogues Enhances Spatial Memory and Protects Against Cholinergic Deficits	p. 363
Role of Inflammation in Stroke: Benefits or Harm?	p. 371
Variations in Neuropathology and Pathophysiology Over Time and Among Areas in a Rat Model of Focal Areas in a Rat Model of Focal Cerebral Ischemia	p. 385
Impairment and Pharmacological Protection of the Blood-Brain Barrier After Head Trauma	p. 393
Pathophysiology of the Blood-Spinal Cord Barrier in Spinal Cord Injury	p. 401
Index	p. 417
Table of Contents provided by Syndetics. All Rights Reserved.

Blood Brain Barrier

Drug Delivery and Brain Pathology

At a Glance

Hardcover

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