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Biotechnology: Bridging Research and Applications : Proceedings of the U.S.-Israel Research Conference on Advances in Applied Biotechnology Biotechnology June 24-30, 1990; Haifa, Israel - Daphne Kamely

Biotechnology: Bridging Research and Applications

Proceedings of the U.S.-Israel Research Conference on Advances in Applied Biotechnology Biotechnology June 24-30, 1990; Haifa, Israel

By: Daphne Kamely (Editor), A.M. Chakrabarty (Editor), Steven E. Kornguth (Editor)

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Published: 31st July 1991
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Biotechnology is advancing at a rapid pace with numerous applications in medicine, industry, agriculture and environmental remediation. Recognizing this, government, industrial and academic research and development invest- ment in biotechnology has expanded rapidly. The past decade has seen the emergence of applications of this technology with a dual-use potential. Mili- tary applications focus on four major areas: biomedical technology, such as vaccine development and medical diagnostics; detection of toxins, chemicals and pathogens; material biotechnology; and biological decontamination, in- cluding biodegradation and bioremediation. This conference emphasizes the non-medical applications of biotechnol- ogy. The first two sessions focus on the synthesis and properties of molecules that may be used in detectors. The traditional approach to detection of chemical and biological agents relied on the development of specific assays or analyses for known agents. Advances in molecular biology have made possible the production of large quantities of toxins which were previously available in minute quantities, and the molecular engineering of toxins and pathogens with specific pharmacologic and physical-chemical properties. In addition to the traditional approaches to detection of specific known compounds, biotechnology now offers generic approaches to detection. Physiological targets, known as receptors, are primary targets for many drugs and toxins. Similarly, pathogens rely on receptors to gain access to cells. These receptors function as sensitive detectors, generating signals which are transduced and amplified.

Foreword
Acknowledgments
Keynote Address: Biological Applications of Synthetic Polypeptidesp. 1
Manufacturing and Biotechnology Synergisms for the Early 2000'sp. 15
Biosensors Based on Solvated Bilayers Attached to Electrodesp. 43
Alternatives to Radioimmunoassayp. 63
The Use of Intact Luminous Bacteria in Analytical Chemistry, Clinical Microbiology and Acute Toxicityp. 79
Deposition of Enzymes by Electropolymerizationp. 89
Computerized Biospecific Electrodesp. 95
NMR-Structural Studies of Membrane Bound Peptides and Proteinsp. 109
DNA as a Biosensor for Environmental Agentsp. 127
Detection of Pathogens with Nucleic Acid Probesp. 141
Structure-Function Relationships, In Vivo Mutability and Gene Amplification in Human Cholinesterases, Targets for Organophosphorus Poisonsp. 153
Assessment of Genetic Damage in Human Tissue by Immunoassayp. 167
Field Operable Devices for Immunological, Molecular and Toxicological Diagnosis - A Review on a Unified Approachp. 179
Design and Properties of Enzymes Immobilized in Sol-Gel Glass Matricesp. 205
Microbial Degradation of Agent Orange and Mustard Related Compoundsp. 221
Surface Active and Drag-Reducing Bacterial Polymersp. 231
Towards Catalytic Antibodies for the Degradation of Toxic Agentsp. 249
Bacterial Heavy Metal Resistance Systems and Possibility of Bioremediationp. 265
The Cholinergic Binding Site: Structure and Applicationp. 289
Outdoor Cultivation of Microalgae in a Closed System for the Production of Valuable Biochemicalsp. 301
Chemical Sensing Applications of Semiconductor Photoluminescencep. 317
High Speed DNA Sequencing and the Analysis of the Human Genomep. 333
Interacting Light Energy with Biocatalytic Assemblies: Biocatalysed Photosynthesis and Photoregulation of Enzymesp. 341
Modifying Specificities of Restriction Enzymesp. 371
Pulsed Laser Fluorometry for Environment Monitoringp. 377
Recognition of the Human CD4 Receptor by the AIDS Virus: A Molecular Target for AIDS Therapeuticsp. 401
Antibody-Catalyzed Concerted Chemical Reactionsp. 413
Engineering Altered Substrate Specificity into Subtilisin BPN'p. 429
Summary of Conferencep. 441
Concluding Discussionp. 445
List of Participantsp. 451
Indexp. 457
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792311447
ISBN-10: 0792311442
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 459
Published: 31st July 1991
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.6
Weight (kg): 1.86