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Biopharmaceutics Applications in Drug Development - Rajesh Krishna

Biopharmaceutics Applications in Drug Development

By: Rajesh Krishna (Editor), Lawrence Yu (Editor)

Hardcover Published: December 2007
ISBN: 9780387723785
Number Of Pages: 396

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Drug performance is a vital aspect of new drug development as it draws on interdisciplinary expertise from both pharmaceutics and pharmacokinetics disciplines. It is at the key interface that the discipline of biopharmaceutics has emerged. The past two decades have witnessed considerable advances in biopharmaceutics, particularly with regard to bioavailability/bioequivalence, product quality and regulatory standards of approval.

Biopharmaceutics Applications in Drug Development presents readers with step-wise, detail-conscious information to develop quality pharmaceuticals. It is composed of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality, with specific focus on integration of regulatory considerations and case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.

Industry Reviews

From the reviews:

"The objective of this book is to present 'an integrated view linking pharmaceutics and the biological consequences to drug development decision making.' It is written primarily for those who work in the pharmaceutical industry applying biopharmaceutics and pharmacokinetics, or interacting with formulation scientists. The book will also be useful for those in academic and research environments. It could be valuable for students of biopharmaceutics in undergraduate or graduate programs in pharmaceutical science, and should find a role as an innovative pharmD curriculum elective." (Joseph Boullata, Doody's Review Service, August, 2008)

Introduction to Biopharmaceutics and its Role in Drug Developmentp. 1
Molecular and Physicochemical Properties Impacting Oral Absorption of Drugsp. 26
Dissolution Testingp. 47
Drug Absorption Principlesp. 75
Evaluation of Permeability and P-glycoprotein Interactions: Industry Outlookp. 101
Excipients as Absorption Enhancersp. 139
Intestinal Transporters in Drug Absorptionp. 175
Bioavailability and Bioequivalencep. 262
A Biopharmaceutical Classification System Approach to Dissolution: Mechanisms and Strategiesp. 290
Food Effects on Drug Bioavailability: Implications for New and Generic Drug Developmentp. 317
In Vitro-In Vivo Correlation on Parenteral Dosage Formsp. 336
In Vitro-In Vivo Correlation in Dosage Form Development: Case Studiesp. 359
Indexp. 383
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780387723785
ISBN-10: 0387723781
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 396
Published: December 2007
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.85 x 16.41  x 2.46
Weight (kg): 0.72

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