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Biomolecular Action of Ionizing Radiation : Medical Physics & Biomedical Engineering - Shirley Lehnert

Biomolecular Action of Ionizing Radiation

Medical Physics & Biomedical Engineering

Paperback

Published: 24th October 2007
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Embracing the transformation of radiation sciences by the recent surge of developments in molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo molecular responses in the body induced by ionizing radiation. With a unique emphasis on medical physics applications, Biomolecular Action of Ionizing Radiation also presents a much needed, in-depth perspective on clinical applications for the treatment of cancer and radiation injuries.

Based on a popular course given by the author at McGill University,the bookplaces the traditional tenets of radiation biology in the context of contemporary cell and molecular biology. Using terms that non-experts in molecular biology can understand, it clarifies the underlying mechanisms of radiation effects on molecular interactions including signal transduction pathways, modes of cell killing, and non-targeted effects. The author subsequently associates key principles and advances with potential applications, including the use of ionizing radiation as a cytotoxic and cytostatic agent, and radiosensitization by targeting molecular intermediates or signaling molecules involved in radiation-induced processes.

Raising the standard for radiation biology texts that are currently available, Biomolecular Action of Ionizing Radiation is an outstanding resource for advanced undergraduate and graduate students in medical physics, radiation oncology, radiation biology, and those who have an interest in the radiation sciences and in cancer treatment.

Introduction
Basic radiation physics and chemistry
Basic cell biology and molecular genetics
Methods of cell and molecular radiobiology
Ionizing radiation effects to the cytoplasm
Damage to DNA by ionizing radiation
Repair of radiation damage to DNA. Cellular response to DNA damage
Chromatin structure and radiation sensitivity
Radiation-induced chromosome damage
Modulation of radiation response via signal transduction pathways
Radiation-induced apoptosis
Early and late responding genes induced by ionizing radiation
Cell death, cell survival, and adaptation
Bystander effects and genomic instability
Tumor radiobiology
Radiation biology of nonmammalian species: three eukaryotes and a bacterium
References
Glossary
Index
Each Chapter contains a Summary section and References
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780750308243
ISBN-10: 0750308249
Series: Medical Physics & Biomedical Engineering
Audience: Tertiary; University or College
Format: Paperback
Language: English
Number Of Pages: 527
Published: 24th October 2007
Publisher: INST OF PHYSICS PUB
Country of Publication: GB
Dimensions (cm): 23.52 x 12.68  x 2.52
Weight (kg): 0.78
Edition Number: 1