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Biomechanics and Cells : Society for Experimental Biology Seminar Series - Fiona Lyall

Biomechanics and Cells

Society for Experimental Biology Seminar Series

By: Fiona Lyall (Editor), A. J. El Haj (Editor)

Hardcover

Published: 27th May 1994
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Although the effects of exercise and mechanical forces on musculoskeletal and cardiovascular systems have been well documented, the actual mechanisms by which mechanical forces act at the cellular level are not well understood. At present, studies of the interaction of mechanical forces with cells encompass many different cell types in various tissues. This volume draws together these apparently disparate observations and makes comparisons between the nature of cellular responses in different tissues. Studies of cells derived from skeletal muscle, bone and cardiovascular tissue are considered to provide a comprehensive synthesis and review of recent work. The volume will be of interest to all those working in musculoskeletal and cardiovascular biology, as well as those taking courses in exercise and sport science, biomechanics and orthopaedics.

"The strengths of this book include the diversity of cell types and physiological responses covered, the significant detail on the putative biological mechanisms by which mechanical stimuli may be transduced by cells, and most of all the variety and detail of the experimental models, preparations, and devices that are described...an interesting collection of articles on mechanical signal transduction by cells in a variety of experimental settings." A.D. McCulloch, Applied Mechanics Review

Preface
Soft Tissue
Signal transduction in vascular cells exposed to cyclic strain
Effects of pressure overload on vascular smooth muscle cells
Effect of increased flow on release of vasoactive substances from vascular endothelial cells
Modulation of endothelium derived relaxing factor activity by flow
Stretch, overload and gene expression in muscle
Stretch sensitivity in stretch receptor muscles
Mechanical interactions with plant cells - a selective overview
Mechanical tensing of cells and chromosome arrangement
Alterations in gene expression induced by low-frequency, low-intensity electromagnetic fields
Hard Tissue
Cellular modelling of mechanical interactions with the skeleton
Mechanical and hormonal influences in vivo cause regional differences in bone remodelling
Mechanically sensitive cells in bone
Mechanical stress and bone development
Applications of homogenous, defined strains to cell cultures
The role of prostaglandin in bone cells as mediators of mechanical strain
Effects of mechanical stretch on actin polymerisation in fibroblasts of the periodontium
Modulation of cartilage extracellular matrix turnover by pulsed electromagnetic fields
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521454544
ISBN-10: 0521454549
Series: Society for Experimental Biology Seminar Series
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 288
Published: 27th May 1994
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 22.8 x 15.2  x 2.1
Weight (kg): 0.59