Biology and Pathology of Astrocyte-Neuron Interactions

By: Sergey Fedoroff (Editor), Bernhard H.J. Juurlink (Editor), J. Ronald Doucette (Editor)

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Hardcover | 30 November 1993

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484 Pages

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25.4 x 17.78 x 2.69

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This volume is made up of papers presented at the Second International Altschul Symposium: Biology and Pathology of Astrocyte-Neuron Interactions. The symposium was held in Saskatoon, Canada at the University of Saskatchewn in May, 1992 in memory of Rudolf Altschul, a graduate of the University of Prague and a pioneer in the fields of the biology of the vascular and nervous systems. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The Altschul Symposia were made possible by an endowment left by Anni Altschul and by other contributions. The symposia are held biennially. One of the greatest challenges for present day scientists is to uncover the mechanisms of brain function. Although cellular anatomy of the nervous system has already been well outlined and indeed was delineated by the beginning of the century, experimental analysis of the function of the brain is relatively recent. The framework of the brain is made up of stellate cells, the astrocytes, which are interconnected by means of their processes, thus presenting a meshwork through which the neurons send their axons, accompanied by oligodendrocytes. Microglia are distributed throughout the brain.

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Non-Fiction Science Biology, Life Sciences Life Sciences in General Neurosciences Medicine Clinical & Internal Medicine Neurology & Clinical Neurophysiology Botany & Plant Sciences Zoology & Animal Sciences Animal Physiology Molecular Biology

Metabolic Interactions between Neurons	p. 1
The Perinodal Astrocyte: Functional and Developmental Considerations	p. 15
Anoxia-Induced Extracellular Ion Shifts in Mammalian CNS White Matter	p. 27
Hyperexcitability of Neurons and Astrocytes in Epileptic Human Cortex	p. 51
Inter-Cellular Signalling by Nitric Oxide	p. 67
Production of Nitrosyl Mediators in Astrocytes	p. 75
The Possible Roles of Astrocytes in Energy Metabolism of the Brain	p. 83
Astroglia: Receptors, Second Messengers, and Function	p. 93
Neurotrophic Factors Produced by Astrocytes Involved in the Regulation of Cholinergic Neurons in the Central Nervous System	p. 103
Olfactory Ensheathing Cells: Factors Influencing the Phenotype of these Glial Celss	p. 117
Role of Peroxidase-Positive Astrocytes in Estradiol-Related Hypothalamic Damage	p. 125
Regulation of Gene Expression in Astrocytes	p. 141
GFAP Gene Expression in Normal and Reactive Astrocytes	p. 153
Astrocytes Can Act as Permissive Subtrates for the Growth of NFG-Sensitive Acons in Vivo	p. 163
Glial-Neuronal Interactions Exemplified by the Synthesis and Actions of Ciliary Neurotrophic Factor	p. 173
How Does Thrombin Cause Neurite Retraction?	p. 181
Neuronal Control of Astrocyte Proliferation	p. 193
The Role of 5-HT[subscript 1A] Receiptors in Development and Adult Plasticity of the Serotonergic System	p. 207
The Role of Substance P in Cytokine Production by Glial Cells	p. 215
Sources and Targets of Cytokines in the Central Nervous System	p. 229
Regulation of Tumor Necrosis Factor-Alpha Gene Expression in the Astrocyte	p. 237
Paracrine and Autocrine Signalling in Regulation of Microglia Survival	p. 247
Antigen Presentation at the Blood-Brain Barrier: A Role for Astrocytes?	p. 263
Oligodendrocytes and the Immune System	p. 271
Perineuronal Glial Reactions in Regeneration of Motoneurons	p. 283
Regulation of Type III Intermediate Filament Protein Genes in Astrocytes during Development and after Injury	p. 291
Heterogeneity of Reactive Astrocytes	p. 303
Inhibition of GFAP Synthesis with Antisense Nucleic Acid Constructs	p. 313
X-Irradiation for Promoting Recovery in Lesioned Adult Mammalian CNS	p. 327
Migration and Fate of Transplanted Astrocytes	p. 335
Morphology of Astroglial Swelling in Culture and in the Edematous Brain: An Adaptive Response to a Disturbed Microenvironment	p. 347
Glial Activation as a Common Denominator in Neurodegenerative Disease: A Hypothesis in Neuropathophysiology	p. 359
Downs's Syndrome and S-100 Protein	p. 383
Astrocyte/Oligodendrocyte Interaction in Association with Reactive Gliosis	p. 395
Astroglial Response to Liver Failure	p. 405
Possible Roles for Astroglia and Microglia in the Pathogenesis of Unconventional Slow Infections	p. 417
Abstracts	p. 431
Contributors	p. 449
Index	p. 455
Table of Contents provided by Blackwell. All Rights Reserved.

Biology and Pathology of Astrocyte-Neuron Interactions

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