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Biology and Pathology of Astrocyte-Neuron Interactions : Altschul Symposia Series - S. Fedoroff

Biology and Pathology of Astrocyte-Neuron Interactions

Altschul Symposia Series

By: S. Fedoroff (Editor), R. Doucette (Editor), Bernhard H. J. Juurlink (Editor), J. Ronald Doucette (Editor)

Hardcover Published: 30th November 1993
ISBN: 9780306445651
Number Of Pages: 458

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This volume is made up of papers presented at the Second International Altschul Symposium: Biology and Pathology of Astrocyte-Neuron Interactions. The symposium was held in Saskatoon, Canada at the University of Saskatchewn in May, 1992 in memory of Rudolf Altschul, a graduate of the University of Prague and a pioneer in the fields of the biology of the vascular and nervous systems. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The Altschul Symposia were made possible by an endowment left by Anni Altschul and by other contributions. The symposia are held biennially. One of the greatest challenges for present day scientists is to uncover the mechanisms of brain function. Although cellular anatomy of the nervous system has already been well outlined and indeed was delineated by the beginning of the century, experimental analysis of the function of the brain is relatively recent. The framework of the brain is made up of stellate cells, the astrocytes, which are interconnected by means of their processes, thus presenting a meshwork through which the neurons send their axons, accompanied by oligodendrocytes. Microglia are distributed throughout the brain.

Metabolic Interactions between Neuronsp. 1
The Perinodal Astrocyte: Functional and Developmental Considerationsp. 15
Anoxia-Induced Extracellular Ion Shifts in Mammalian CNS White Matterp. 27
Hyperexcitability of Neurons and Astrocytes in Epileptic Human Cortexp. 51
Inter-Cellular Signalling by Nitric Oxidep. 67
Production of Nitrosyl Mediators in Astrocytesp. 75
The Possible Roles of Astrocytes in Energy Metabolism of the Brainp. 83
Astroglia: Receptors, Second Messengers, and Functionp. 93
Neurotrophic Factors Produced by Astrocytes Involved in the Regulation of Cholinergic Neurons in the Central Nervous Systemp. 103
Olfactory Ensheathing Cells: Factors Influencing the Phenotype of these Glial Celssp. 117
Role of Peroxidase-Positive Astrocytes in Estradiol-Related Hypothalamic Damagep. 125
Regulation of Gene Expression in Astrocytesp. 141
GFAP Gene Expression in Normal and Reactive Astrocytesp. 153
Astrocytes Can Act as Permissive Subtrates for the Growth of NFG-Sensitive Acons in Vivop. 163
Glial-Neuronal Interactions Exemplified by the Synthesis and Actions of Ciliary Neurotrophic Factorp. 173
How Does Thrombin Cause Neurite Retraction?p. 181
Neuronal Control of Astrocyte Proliferationp. 193
The Role of 5-HT[subscript 1A] Receiptors in Development and Adult Plasticity of the Serotonergic Systemp. 207
The Role of Substance P in Cytokine Production by Glial Cellsp. 215
Sources and Targets of Cytokines in the Central Nervous Systemp. 229
Regulation of Tumor Necrosis Factor-Alpha Gene Expression in the Astrocytep. 237
Paracrine and Autocrine Signalling in Regulation of Microglia Survivalp. 247
Antigen Presentation at the Blood-Brain Barrier: A Role for Astrocytes?p. 263
Oligodendrocytes and the Immune Systemp. 271
Perineuronal Glial Reactions in Regeneration of Motoneuronsp. 283
Regulation of Type III Intermediate Filament Protein Genes in Astrocytes during Development and after Injuryp. 291
Heterogeneity of Reactive Astrocytesp. 303
Inhibition of GFAP Synthesis with Antisense Nucleic Acid Constructsp. 313
X-Irradiation for Promoting Recovery in Lesioned Adult Mammalian CNSp. 327
Migration and Fate of Transplanted Astrocytesp. 335
Morphology of Astroglial Swelling in Culture and in the Edematous Brain: An Adaptive Response to a Disturbed Microenvironmentp. 347
Glial Activation as a Common Denominator in Neurodegenerative Disease: A Hypothesis in Neuropathophysiologyp. 359
Downs's Syndrome and S-100 Proteinp. 383
Astrocyte/Oligodendrocyte Interaction in Association with Reactive Gliosisp. 395
Astroglial Response to Liver Failurep. 405
Possible Roles for Astroglia and Microglia in the Pathogenesis of Unconventional Slow Infectionsp. 417
Abstractsp. 431
Contributorsp. 449
Indexp. 455
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306445651
ISBN-10: 0306445654
Series: Altschul Symposia Series
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 458
Published: 30th November 1993
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 2.7
Weight (kg): 2.5