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Biochemistry of Redox Reactions : Metabolism of Drugs and Other Xenobiotics - Bernard Testa

Biochemistry of Redox Reactions

Metabolism of Drugs and Other Xenobiotics

By: Bernard Testa (Editor), John Caldwell (Editor)

Hardcover Published: 25th October 1994
ISBN: 9780126853919
Number Of Pages: 471

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Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: First in a set of books to provide a comprehensive coverage of drug metabolism; Opening chapter provides a general introduction to the complete set of books; Other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates, and drug-enzyme interactions; Extensive detailed diagrams of reaction pathways and chemical structures
* First in a set of books providing a comprehensive coverage of drug metabolism
* Opening chapter provides a general introduction to the complete set of books
* Other chapters cover reaction mechanisms, catalytic cycles, regio and stereoselectivities, types of substrates, reactivity of intermediates and drug-enzyme interactions
* Extensive detailed diagrams of reaction pathways and chemical structures

"What I really like and what I would like to emphasize is the fact that this book is not only a comprehensive collection of biochemical data on redox mechanisms, but is legible as well. The personal style and the commitment of the author that can be felt between the lines contributes to my unreserved recommendation to have this book on the shelf of everyone who is busy in the field of making compounds that interact with living systems." --Pharmaceutica Acta Helvetiae "Testa's deep comprehension of his subject and his scholarly commitment make sure that this volume is not only comprehensive but eminently readable." --SIR JAMES BLACK, Nobel Laureate "...several books have appeared on the metabolism of xenobiotic compounds, but this new text, by one of the most respected researchers in the field, has set the benchmark for all that follow... indispensible to all serious students of drug metabolims, and a collection to treasure." --Laurence J. Kim, University of Surrey, in ISSX NEWSLETTER "The overall impression is one of a book that is extensively and well researched with the facts clearly laid out in a very readable style." --David Needham in BRITISH TOXICOLOGY SOCIETY NEWSLETTER "The book would be very applicable as a text or reference for graduate and advanced undergraduate courses in toxicology, drug metabolism, medicinal chemistry and pharmacy. Professor Testa has done a very admirable job of compiling and presenting material of the subject. The book is strongly recommended as a course text and general reference, and I look forward to seeing the remaining three volumes in the series." --F. Peter Guengerich in PHARMACEUTICAL NEWS

Xenobiotic Metabolism: The Global View
Xenobiotic Metabolism: The Biochemical View
Dehydrogenation of Alcohols and Aldehydes, Carbonyl Reduction
The Nature and Functioning of Cytochromes P450 and Flavin-Containing-Monooxygenases
Carbon Oxidations Catalyzed by Cytochromes P450
Monooxygenase-Catalyzed N-C Cleavage
Monooxygenase-Catalyzed Oxidation of Oxygen- and Sulfur-Containing Compounds
Oxidative Dehalogenation and Dealkylation of Organometallics
Oxidations Catalyzed by Various Oxidases and Monooxygenases
Reactions Catalyzed by Peroxidases
Oxidation of Mercury, Silicon, Phosphorus, Arsenic, Selenium, and Halogens
Reductions Catalyzed by Cytochrome P450 and Other Oxidoreductases
Various Enzymatic and Nonenzymatic Reactions
Conclusion and Outlook
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780126853919
ISBN-10: 0126853916
Series: Metabolism of Drugs and Other Xenobiotics
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 471
Published: 25th October 1994
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 3.18
Weight (kg): 0.89