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Biochemistry and Physiology of the Neutrophil - Steven W. Edwards

Biochemistry and Physiology of the Neutrophil


Published: 25th March 1994
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This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of this cell, highlighting the mechanisms by which they seek out and destroy pathogenic microorganisms. The development of these cells during haematopoiesis is described and the mechanisms that lead to the production of reactive oxidants and the intracellular signal transduction systems that lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally, there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.

"...a useful basic reference and I would recommend it to immunologists, microbiologists, biochemists, physiologists, infectious disease specialists, hematologists, or to anyone whose interest lies in immunology or microbiology." John O. Naim, Immunological Investigations

Neutrophils and host defence: the fight against infection
The development and structure of neutrophils
The generation and recognition of neutrophil-activating factors: structure and function of neutrophil receptors
The cytoskeleton: the molecular framework regulating cell shape and the traffic of intracellular components
The respiratory burst: the generation of reactive oxygen metabolites and their role in microbial killing
Neutrophil activation: the production of intracellular signalling molecules
Neutrophil priming: regulation of neutrophil function during inflammatory activation
Disorders of neutrophil function
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521416986
ISBN-10: 0521416981
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 320
Published: 25th March 1994
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 22.8 x 15.2  x 1.9
Weight (kg): 0.59