Biochemistry and Molecular Genetics of Cancer Metastasis

One - Biochemistry and Molecular Biology Aspects.- 1. Biochemical and molecular biology approaches to study cancer metastases.- 2. Use of the chick embryo in studying the molecular genetics of metastasis.- 3. Integral membrane adhesion glycoproteins: What is their fate during metastasis?.- 4. Peptide fragments of fibronectin and laminin: Role in cell adhesion and inhibition of experimental tumor metastasis.- 5. Role of ras oncogenes in experimental models of metastasis.- 6. Expression of p21ras gene products in fresh primary and metastatic human tumor tissue.- 7. A role for differentiation arrest in the development of neural crest tumors.- 8. Genetic and epigenetic regulation of the metastatic phenotype: A basis for resolving the controversy regarding its selective or random nature and variable phenotypic stability.- 9. Cytochemical cell typing of metastatic tumors according to their cytoskeletal proteins.- 10. Biochemistry and molecular biology RAW117 large cell lymphoma.- 11. Karyotypic progression and metastasis formation of human tumors.- 12. Morphological and functional alterations of occludens, adherens, and gap junctions in cancer.- 13. Pattern of basement membrane degradation by metastatic tumor cell enzymes.- Two - Immunologic Mechanisms.- 14. Gene products of the major histocompatibility complex control the metastatic phenotype of tumor cells.- 15. Generation of metastatic cells via somatic cell fusion: A possible mechanism for tumor progression in-vivo.- 16. The recognition and destruction of metastatic cells by tumoricidal macrophages.- 17. Biological response modifiers for the therapy of metastases.- 18. Differences in cell surface characteristics of poorly and highly metastatic Lewis lung tumor variants.- 19. Characteristics of LL2 and its lectin-resistant not metastasizing variants.- 20. A role for cell surface sialic acid in liberating metastatic tumor cells from host control.- Three - Clinical Perspectives and Applications.- 21. Tumor heterogeneity and empirical clinical cancer chemotherapy: Current status and future prospects.- 22. Hormonal regulation of metastases: Prospects for pharmacological manipulation.- 23. Use of anti-tumor MABs for diagnosis and immunotherapy of human tumors.- 24. New approaches to the adoptive immunotherapy of established metastatic cancer using lymphokine-activated killer cells and recombinant interleukin-2.- 25. Preclinical screening of biological response modifiers: Application to the treatment of metastatic disease.