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Bioassay Methods in Natural Product Research and Drug Development : PROCEEDINGS OF THE PHYTOCHEMICAL SOCIETY OF EUROPE - Lars Bohlin

Bioassay Methods in Natural Product Research and Drug Development


By: Lars Bohlin (Editor), Jan G. Bruhn (Editor)

Hardcover Published: January 1999
ISBN: 9780792354802
Number Of Pages: 203

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Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997, in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Plant Biodiversity - Evolutionary and Ecological Perspectivesp. 1
Chemodiversity and the Biological Role of Secondary Metabolites, Some Thoughts for Selecting Plant Material for Drug Developmentp. 11
Evolving Strategies for the Selection, Dereplication and Prioritization of Antitumor and HIV-Inhibitory Natural Products Extractsp. 25
Screening Methods for Detection and Evaluation of Biological Activities of Plant Preparationsp. 37
The Use of Receptor Binding, a Very Specific, High Capacity Screening Method, in the Identification of Biologically Active Components from Natural Sourcesp. 53
Biological and Chemical Evaluation of Plant Extracts and Subsequent Isolation Strategyp. 67
Natural Products with Antiprotozoal Activityp. 81
In-Vitro Assays for Activity-Guided Enrichment of Immunomodulatory Plant Constituentsp. 101
Search for Potent Immunomodulatory Agents from Plants and Other Sourcesp. 113
Cyclooxygenase and 5-Lipoxygenase as Targets for Medicinal Plant Researchp. 119
Natural Products in Drug Discovery and Developmentp. 143
QPRI's System for Screening of Natural Productsp. 151
Phytera's Strategy for the Discovery of Novel Anti-Infective Agents from Plant Cell Culturesp. 159
Expediting Drug Development Through the Use of Plantsp. 167
The Future Role of Natural Products in Drug Discoveryp. 183
Indexp. 194
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792354802
ISBN-10: 079235480X
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 203
Published: January 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 24.13 x 16.51  x 1.27
Weight (kg): 0.48