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Bioactive Heterocycles IV : Topics in Heterocyclic Chemistry - Mahmud T. H. Khan

Bioactive Heterocycles IV

Topics in Heterocyclic Chemistry

By: Mahmud T. H. Khan (Editor)

Hardcover Published: 11th October 2007
ISBN: 9783540734031
Number Of Pages: 317

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This volume contains nine more contributions from expert researchers of the ?eld, providing readers with in depth and current research results regarding therespective topics. In the ?rst chapter, Flemming et al. review the chemistry, biosynthesis, metabolism and biological activities of tetrahydrocannabinol and its deri- tives. Hansch and Verma contribute to the quantitative structure-activity re- tionship (QSAR) analysis of heterocyclic topoisomerase I and II inhibitors. These inhibitors,knowntoinhibit either enzyme, actasantitumoragentsand are currently used in chemotherapy and in clinicaltrials. In the third chapter, Khan reviews some aspects of molecular modeling studies on biologically active alkaloids, brie?y providing considerations on themodeling approaches. In next chapter, Khan and Ather review different aspects of the microbial transformationsof theimportant nitrogenousmolecules, as they have diverse biological activities. This chapter provides a critical update of the microbial transformations reported in recent years, targeting novel biocatalysts from microbes. In the ?fth chapter, Hamdi and Dixneuf describe the synthesis of triazoles andcoumarins molecules andtheirphysiologicalactivities. Maiti and Kumar, in their contribution, review the physicochemical and nucleic acid binding properties of several isoquinoline alkaloids (berberine, palmatine and coralyne) and their derivatives under various environmental conditions. Inchapterseven,Berlinckdescribesvarietiesofpolycyclicdiaminealkaloids such as halicyclamines, 'upenamide, xestospongins, araguspongines, hali- clamines, haliclonacyclamines, arenosclerins, ingenamines and the mad- gamines, etc.,and their synthesis as well as biologicalactivities.

Industry Reviews

From the reviews:

"This latest volume in the series Topics in Heterocyclic Chemistry is a collection of nine chapters covering a diverse assortment of natural and synthetic nitrogen- and oxygen- containing heterocycles. ... A Subject Index and an Author Index for Volumes 1-10 are included. ... the structural drawings are excellent. ... to academic libraries that are collecting volumes from the Topics in Heterocyclic Chemistry series." (Gordon W. Gribble, Journal of the American Chemical Society, Vol. 130 (19), 2008)

T. Flemming, R. Muntendam, C. Steup, O. Kayser: Chemistry and Biological Activity of Tetrahydrocannabinol and its Derivatives.- C. Hansch, R.P. Verma: Quantitative Structure-Activity Relationships of Heterocyclic Topoisomerase I and II Inhibitors.- M.T.H. Khan: Molecular Modeling of the Biologically Active Alkaloids - A Critical Review.- M.T.H. Khan, A. Ather: Microbial Transformation of Nitrogenous Compounds - An Update N. Hamdi, P.H. Dixneuf: Synthesis of Triazoles and Coumarins Compounds and Their Physiological Activity.- M. Maiti, G.S. Kumar: Protoberberine Alkaloids: Physico-chemical and Nucleic Acid Biding Properties.- R.G.S. Berlinck: Polycyclic Diamine Alkaloids from Marine Sponges.- P. Buzzini, B. Turchetti, F, Ieri, M. Goretti, E. Branda, N. Mulinacci, A. Romani: Catechins and Proanthocyanidins: Naturally Occurring O-heterocycles with Antimicrobial Activity.- H. Cerecetto, M. Gonzàlez: Benzofuroxan and Furoxan. Chemistry and Biology

ISBN: 9783540734031
ISBN-10: 3540734031
Series: Topics in Heterocyclic Chemistry
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 317
Published: 11th October 2007
Country of Publication: DE
Dimensions (cm): 26.29 x 16.28  x 2.34
Weight (kg): 0.71

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