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Binding Constants : The Measurement of Molecular Complex Stability - Kenneth A. Connors

Binding Constants

The Measurement of Molecular Complex Stability

Hardcover

Published: 4th May 1987
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This unique book presents a systematic review of the methods for the determination of binding constants of complex formation in solution. Material has been gathered which has been scattered throughout the literature of several separate fields. Offered here are methods from the areas of acid-based chemistry, metal- ion coordination compounds, hydrogen-bonding, charge-transfer complexation, hydrophobic interaction and protein-binding. The relevant thermodynamics, modelling, statistics and regression analysis, and interpretation of data are discussed, along with fresh discussions of random association (contact complexes), selection of standard states and comparison of results. All of the experimental methods useful for measuring these equilibrium constants are treated, including those based on spectrophotometry, nuclear magnetic resonance, reaction kinetics, potentiometry, solubility, liquid-liquid partitioning, dialysis, chromatography, flourimetry and many others.

GENERAL MATTERS.

Molecular Association.

Binding Constants.

Statistical Treatment of Data.

THE METHODS.

Optical Absorption Spectroscopy.

Magnetic Resonance Spectroscopy.

Reaction Kinetics.

Potentiometry.

Solubility Measurement.

Interpretation of Solubility Diagrams.

Liquid-Liquid Partitioning.

Dialysis.

Chromatography.

Additional Methods.

The Method of Choice.

Appendixes.

Index.

ISBN: 9780471830832
ISBN-10: 0471830836
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 432
Published: 4th May 1987
Country of Publication: US
Dimensions (cm): 23.65 x 15.55  x 2.81
Weight (kg): 0.68
Edition Number: 1