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Bilayer Lipid Membranes. Structure and Mechanical Properties - Tibor Hianik

Bilayer Lipid Membranes. Structure and Mechanical Properties

Hardcover Published: 31st August 1995
ISBN: 9780792335511
Number Of Pages: 436

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The present monograph reviews the results of experimental and theoretical research into the mechanical properties of lipid bilayers - the structural basis of biological membranes. The relation between membrane structure and viscoelastic properties is analyzed and new methods of measurement of the modulus of elasticity, particularly in transversal direction, developed by the authors, are presented. The authors use an approach fundamentally different from the usual one, namely an analysis of the lipid bilayer dynamics during various modes of deformation, arriving at a new, 'three-layer' model of lipid bilayer deformation, which accounts for the great heterogeneity of biomembranes. A wide variety of methods of measuring the macroscopic parameters of membranes as well as correlations between these parameters are revealed and discussed. The problem of dynamic changes of mechanical properties of lipid bilayers in the course of conformational transition of integral proteins, which has never before been sufficiently dealt with, is discussed here in detail. The extensive experimental work of the authors is presented, work which comprises many studies of viscoelastic parameters of reconstituted membrane systems with a defined functional response, e.g. insulin reception. It is demonstrated that during conformational changes of proteins, the structure of a bilayer undergoes transition reaching new stable state of the membranes.
This book is the first one to contain a comprehensive analysis of long-distance interaction in lipid bilayers, and of molecular mechanisms of mechanoreception. The insights and methods presented here will be useful for many scientists and graduate students whose work is in biophysics, membranology, physiology, medicine, pharmacology, bioelectronics, electrochemistry and colloid chemistry.

The elasticity and viscosity of biological membranesp. 1
The measurement of the elasticity modulus [actual symbol not reproducible] of bilayer lipid membranes in a transversal directionp. 19
Methods to measure the viscoelasticity of bilayer lipid membranes and liposomesp. 88
The peculiarity of the electrical field in membranes and an evaluation of their capacitancep. 138
The bilayer lipid membrane as a viscoelastic bodyp. 158
The application of the phenomena of the generation of higher current harmonics to the solution of different biophysical tasks and a comparison of microscopic and macroscopic parameters of lipid bilayersp. 194
The mechanical properties of lipid bilayer under different actionp. 259
The mechanical and thermodynamical properties of lipid bilayer due to the incorporation and conformation changes of membrane proteinsp. 289
The distortion of the structure of lipid bilayer around membrane proteins and the problems of long-distance interactionsp. 348
The mechanics of lipid bilayers and the problems of mechanoreceptionp. 371
Epiloguep. 407
Bibliographyp. 409
Indexp. 430
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792335511
ISBN-10: 0792335511
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 436
Published: 31st August 1995
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 2.54
Weight (kg): 0.81

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