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Autoimmunity - Andrzej Gorski

Autoimmunity

By: Andrzej Gorski (Editor), Hubert Krotkiewski (Editor), Michal Zimecki (Editor)

Hardcover Published: October 2001
ISBN: 9781402000379
Number Of Pages: 207

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This book presents an excellent review of the mechanisms underlying the phenomena of autoimmunity. It provides not only an update of the field's state of the art, but also presents new concepts in the fundamentals and treatment of autoimmune disorders. The finest example of the new approach is understanding the nature of autoimmunity and the treatment of autoimmune diseases is the introductory article. The author opposes the current dogma that autoimmune disorders should be treated with immunosuppressors, and postulates rather the activation of the immune system, which may lead to redirecting the immune response to the protective, Th-2 type of immunity. A series of articles deals with several aspects of the subject, such as the generation, progression, and regulation of autoimmune phenomena. The roles of pathogens, apoptosis, cytokines, complement components, and regulatory T cells are described, as well as the association between the immune and neurohormonal systems in major autoimmune disorders. This is not a textbook, but it is highly recommended for clinicians and university workers, and as supplementary reading for lecturers and students.

Preface
The Paradigms of Causality and Treatment for Autoimmune Diseasep. 1
Uncovering the Differences between T Cell Tolerance and Immunityp. 11
The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: Generation, Specificity and Mode of Actionp. 27
Epitope: Spreading a Mechanism for Progression of Autoimmune Diseasep. 39
A Role of NF-[kappa]B and the Proteasome in Autoimmunityp. 49
Complement Regulatory Proteins and Autoimmunityp. 73
Pathogenic Immunity in Theiler's Virus-Induced Demyelinating Disease: a Viral Model for Multiple Sclerosisp. 83
Evidence that Fas and FasL Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitisp. 95
The Role of Cytokines in Experimental Autoimmune Encephalomyelitisp. 109
Involvement of Apoptotic Protease Cascade for Tissue Destruction in Sjogren's Syndromep. 129
Is Lack of Peripheral Tolerance Induction a Cause for Diabetes in the Non-Obese Diabetic Mouse?p. 139
Neuro-Endocrine-Immune Axis in Human Rheumatoid Arthritisp. 161
The Role of T Cells in Rheumatoid Arthritisp. 183
Indexp. 197
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9781402000379
ISBN-10: 1402000375
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 207
Published: October 2001
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 0.64
Weight (kg): 0.54

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