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Asymmetric Fluoroorganic Chemistry : Synthesis, Applications, and Future Directions - P.V. Ramachandran

Asymmetric Fluoroorganic Chemistry

Synthesis, Applications, and Future Directions

Hardcover

Published: 3rd February 2000
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The substitution of fluorine in an organic molecule increases its chemical stability and changes its reactivity, sometimes leading to substantially more effective medicines, pesticides, and herbicides. This book collects current work on the synthesis of these compounds.

"Presents 20 papers from an August 1998 symposium report on the state of the art in asymmetric fluoroorganic chemistry. In a lead chapter, one of the pioneers of the field discusses fluorine-containing chiral compounds of biomedical interest. Later chapters are organized in sections on reagent- and substrate-controlled asymmetric synthesis, synthesis of fluorine-containing target molecules, bioorganic synthesis, and asymmetric fluoroorganic compounds in materials chemistry, agrochemistry, and pharmacy. Of interest to organic, materials, and medicinal chemists. The editor is affiliated with Purdue University."--SciTech Book News "Presents 20 papers from an August 1998 symposium report on the state of the art in asymmetric fluoroorganic chemistry. In a lead chapter, one of the pioneers of the field discusses fluorine-containing chiral compounds of biomedical interest. Later chapters are organized in sections on reagent- and substrate-controlled asymmetric synthesis, synthesis of fluorine-containing target molecules, bioorganic synthesis, and asymmetric fluoroorganic compounds in materials chemistry, agrochemistry, and pharmacy. Of interest to organic, materials, and medicinal chemists. The editor is affiliated with Purdue University."--SciTech Book News "Presents 20 papers from an August 1998 symposium report on the state of the art in asymmetric fluoroorganic chemistry. In a lead chapter, one of the pioneers of the field discusses fluorine-containing chiral compounds of biomedical interest. Later chapters are organized in sections on reagent- and substrate-controlled asymmetric synthesis, synthesis of fluorine-containing target molecules, bioorganic synthesis, and asymmetric fluoroorganic compounds in materials chemistry, agrochemistry, and pharmacy. Of interest to organic, materials, and medicinal chemists. The editor is affiliated with Purdue University."--SciTech Book News "Presents 20 papers from an August 1998 symposium report on the state of the art in asymmetric fluoroorganic chemistry. In a lead chapter, one of the pioneers of the field discusses fluorine-containing chiral compounds of biomedical interest. Later chapters are organized in sections on reagent- and substrate-controlled asymmetric synthesis, synthesis of fluorine-containing target molecules, bioorganic synthesis, and asymmetric fluoroorganic compounds in materials chemistry, agrochemistry, and pharmacy. Of interest to organic, materials, and medicinal chemists. The editor is affiliated with Purdue University."--SciTech Book News "Presents 20 papers from an August 1998 symposium report on the state of the art in asymmetric fluoroorganic chemistry. In a lead chapter, one of the pioneers of the field discusses fluorine-containing chiral compounds of biomedical interest. Later chapters are organized in sections on reagent- andsubstrate-controlled asymmetric synthesis, synthesis of fluorine-containing target molecules, bioorganic synthesis, and asymmetric fluoroorganic compounds in materials chemistry, agrochemistry, and pharmacy. Of interest to organic, materials, and medicinal chemists. The editor is affiliated withPurdue University."--SciTech Book News

Prefacep. ix
Fluorine-Containing Chiral Compounds of Biomedical Interestp. 1
Reagent-Controlled Asymmetric Synthesis
Asymmetric Synthesis of Fluoroorganic Compounds via Chiral Organoboranesp. 22
Catalytic Asymmetric Synthesis of Fluoroorganic Compounds: Mukaiyama-Aldol and Henry Reactionsp. 38
Asymmetric Fluorination of [alpha]-Amino Ketones: Synthesis of Monofluoroketomethylene Peptide Isosteres and Related Compoundsp. 52
Asymmetric Friedel-Crafts Reactions with Fluoral Catalyzed by Chiral Binaphthol-Derived Titanium Catalystsp. 60
Substrate-Controlled Asymmetric Synthesis
Biomimetic, Reducing Agent-Free Reductive Amination of Fluorocarbonyl Compounds: Practical Asymmetric Synthesis of Enantiopure Fluoroamines and Amino Acidsp. 74
Stereoselective and Enantioselective Synthesis of New Fluoroalkyl Peptidomimetic Units: Amino Alcohols and Isoserinesp. 84
Asymmetric Synthesis of Fluoroalkyl Amino Compounds via Chiral Sulfoxidesp. 98
Studies Toward the Syntheses of Functionalized, Fluorinated Allyl Alcoholsp. 117
Stereoselective Synthesis of [beta]-Fluoroalkyl [beta]-Amino Alcohols Unitsp. 127
Diastereoselective Construction of Novel Sugars Containing Variously Fluorinated Methyl Groups as Intermediates for Fluorinated Aldolsp. 142
Synthesis of Fluoroorganic Targets
Synthesis of Enantiopure Fluorine-Containing Taxoids and Their Use as Anticancer Agents as well as Probes for Biomedical Problemsp. 158
The Synthesis of a Series of Fluorinated Tribactamsp. 182
Bioorganic Synthesis of Asymmetric Fluoroorganic Compounds
Chemical and Biochemical Approaches to the Enantiomers of Chiral Fluorinated Catecholamines and Amino Acidsp. 194
Natural Products Containing Fluorine and Recent Progress in Elucidating the Pathway of Fluorometabolite Biosynthesis in Streptomyces cattleyap. 210
Asymmetric Fluoroorganic Chemistry in Materials Chemistry
Synthetic Aspects of Fluorine-Containing Chiral Liquid Crystalsp. 226
Resolution of Racemic Perfluorocarbons through Self-Assembly Driven by Electron Donor-Acceptor Intermolecular Recognitionp. 239
Catalytic Asymmetric Synthesis of Diastereomeric [alpha]- or [beta]-CF[subscript 3] Liquid Crystalline Molecules: Conformational Probe for Anti-Ferroelectricity and Self-Assembly for Spontaneous Chiral Resolution of the Racemates
Asymmetric Fluoroorganic Chemistry in Agrochemistry and Pharmacy
Chiral 3-Aryl-4-halo-5-(trifluoromethyl)pyrazoles: Synthesis and Herbicidal Activity of Enantiomeric Lactate Derivatives of Aryl-Pyrazole Herbicidesp. 272
Chiral Fluorinated Anestheticsp. 282
Indexes
Author Indexp. 294
Subject Indexp. 295
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780841236394
ISBN-10: 0841236399
Series: ACS Symposium Series
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 464
Published: 3rd February 2000
Publisher: American Chemical Society
Country of Publication: US
Dimensions (cm): 23.6 x 15.8  x 2.1
Weight (kg): 0.56