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Aspartic Proteinases Vol. 362 : Structure, Function, Biology and Biomedical Implications :  Structure, Function, Biology and Biomedical Implications - Kenji Takahashi

Aspartic Proteinases Vol. 362 : Structure, Function, Biology and Biomedical Implications

Structure, Function, Biology and Biomedical Implications

By: Kenji Takahashi (Editor)

Hardcover Published: 1995
ISBN: 9780306448300
Number Of Pages: 629

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Proceedings of the Fifth International Conference on Aspartic Proteinases, held in Gifu, Japan, September 1993. The purpose of the conference was to present and discuss new information on the structure, function, and biology, and related topics, including biomedical implications, of aspartic protein

Comparison of the Active Site Specificity of the Aspartic Proteinases Based on a Systematic Series of Peptide Substratesp. 1
The Molecular Structure of Human Progastricsin and Its Comparison with that of Porcine Pepsinogenp. 11
A New Way of Looking at Aspartic Proteinase Structures: A Comparison of Pepsin Structure to Other Aspartic Proteinases in the Near Active Site Regionp. 19
Rearranging Pepsinogen and Pepsin by Protein Engineeringp. 33
Comparative Investigations on Pig Gastric Proteases and Their Zymogensp. 41
Non-Mammalian Vertebrate Pepsinogens and Pepsins: Isolation and Characterizationp. 53
Transcription Regulation of Human and Porcine Pepsinogen Ap. 67
A Comparative Study on Amino Acid Sequences of Three Major Isoforms of Human Pepsin Ap. 77
Molecular Mass Determination by Electrospray Mass Spectrometry of Human Pepsins, Gastricsin, and Porcine Pepsin A Variantsp. 83
Evidence for Electrostatic Interactions in the S[subscript 2] Subsite of Porcine Pepsinp. 91
Protein Engineering of Surface Loops: Preliminary X-Ray Analysis of the CHY155-165RHI Mutantp. 95
Seminal Progastricsinp. 101
Effects of Hydrocortisone on the Pepsinogen-Producing Cells in Rat Stomach Mucosap. 107
Effects of Omeprazole, a Proton Pump Inhibitor, on Pepsinogen-Producing Cells, with Special Reference to Neonatal Developmentp. 115
Transcription of Embryonic Chick Pepsinogen Gene Is Affected by Mesenchymal Signals through Its 5'-Flanking Regionp. 125
Serum Pepsinogen Values as Possible Markers for Evaluating the Possibility of Peptic Ulcer Recurrence under H[subscript 2]-Blocker Half-Dose Maintenance Therapyp. 131
The Clinical Application of the Serum Pepsinogen I and II Levels as a Mass Screening Method for Gastric Cancerp. 139
A Minute Gastric Cancer Detected by a New Screening Method Using Serum Pepsinogen I and IIp. 145
Two Cases of Early Colorectal Cancer Associated with Gastric Adenoma Detected by Serum Pepsinogen Screening Methodp. 149
Comparisons of the Three-Dimensional Structures, Specificities and Glycosylation of Renins, Yeast Proteinase A and Cathepsin Dp. 155
Discovery of Inhibitors of Human Renin with High Oral Bioavailabilityp. 167
Structure of Human Cathepsin D: Comparison of Inhibitor Binding and Subdomain Displacement with Other Aspartic Proteasesp. 181
Cathepsin D Crystal Structures and Lysosomal Sortingp. 193
Isolation and Characterization of Human Gastric Procathepsin E and Cathepsin Ep. 201
Isolation, Characterization, and Structure of Procathepsin E and Cathepsin E from the Gastric Mucosa of Guinea Pigp. 211
Cathepsin E and Cathepsin D: Biosynthesis, Processing, and Subcellular Locationp. 223
Glycoproteins of the Aspartyl Proteinase Gene Family Secreted by the Developing Placentap. 231
Structure and Possible Function of Aspartic Proteinases in Barley and Other Plantsp. 241
Aspartic Proteinases (Cyprosins) from Cynara cardunculus spp. flavescens cv. Cardoon; Purification, Characterisation, and Tissue-Specific Expressionp. 255
Acid-Activation of Rat Protein following Non-Proteolytic Alterationp. 267
Human Procathepsin D: Three-Dimensional Model and Isolationp. 273
Identification of Five Molecular Forms of Cathepsin D in Bovine Milkp. 279
Site-Directed Mutagenesis of a Disulfide Bridge in Cathepsin D: Expression, Activation, Purification, and Characterizationp. 285
Expression of Rat Cathepsin D cDNA in Saccharomyces cerevisiae: Intracellular Sorting of Cathepsin D to Yeast Vacuolep. 289
Molecular Cloning and Immunocytochemical Localization of Jasmonic Acid Inducible Cathepsin D Inhibitors from Potatop. 293
Purification and Characterization of an Acid Proteinase from Dirofilaria immitis Wormsp. 299
Inhibition and Entrapment of Aspartic Proteinases by [alpha][subscript 2]-Macroglobulinp. 305
Recombinant Human Cathepsin Ep. 315
Expression of Human Cathepsin E in Methylotrophic Yeast, Pichia pastorisp. 319
Purification and Characterization of Recombinant Human Cathepsin Ep. 325
Comparison of Biochemical Properties of Natural and Recombinant Cathepsin Ep. 331
Increased Expression and Specific Localization of Cathepsins E and D in Vulnerable Brain Regions of Aged and Postischemic Ratsp. 335
Characterization of Cathepsins E and D Accumulated at Early Stages of Neuronal Damage in Hippocampal Neurons of Ratsp. 341
Functional Aspects of Cathepsin E: Is It an Embryonic or Fetal Type of Aspartic Proteinase?p. 345
Tissue- and Cell-Specific Control of Guinea Pig Cathepsin E Gene Expressionp. 349
Cathepsin E Is Expressed in Fetal Rat Glandular Stomach Epithelial Cells in Primary Culture in the Absence of Mesenchymesp. 357
Cathepsin E Expressed in Pancreatic Cancerp. 363
Plant Aspartic Proteinases from Cynara cardunculus spp. flavescens cv. Cardoon; Nucleotide Sequence of a cDNA Encoding Cyprosin and Its Organ-Specific Expressionp. 367
Cardosin A and B, Aspartic Proteases from the Flowers of Cardoonp. 373
Mechanism of Autoprocessing of a Mini-Precursor of the Aspartic Protease of Human Immunodeficiency Virus Type Ip. 379
Mutants of HIV-1 Protease with Enhanced Stability to Autodegradationp. 387
Identification of Amino Acid Residues of the Retroviral Aspartic Proteinases Important for Substrate Specificity and Catalytic Efficiencyp. 399
Inhibitor-Resistant Mutants of the HIV-1 Aspartic Proteasep. 407
Design and Synthesis of HIV Protease Inhibitors Containing Allophenylnorstatine as a Transition-State Mimicp. 413
Breaking the Shackles of the Genetic Code: Engineering Retroviral Proteases through Total Chemical Synthesisp. 425
X-Ray Structure of a Tethered Dimer for HIV-1 Proteasep. 439
Structure of HIV-1 Protease with KNI-272: A Transition State Mimetic Inhibitor Containing Allophenylnorstatinep. 445
Molecular Dynamics of HIV-1 Protease in Complex with a Difluoroketone-Containing Inhibitor: Implications for the Catalytic Mechanismp. 451
Activated Dynamics of Flap Opening in HIV-1 Proteasep. 455
Computer Simulation and Analysis of the Reaction Pathway for the Decomposition of the Hydrated Peptide Bond in Aspartic Proteasesp. 461
Activities of Precursor and Tethered Dimer Forms of HIV Proteinasep. 467
Site-Directed Mutagenesis of HIV-1 Protease: Generation of Mutant Proteases with Increased Stability to Autodigestionp. 473
Molecular Modeling of the Structure of FIV Proteasep. 479
Processing, Purification, and Kinetic Characterization of the Gag-Pol Encoded Retroviral Proteinase of Myeloblastosis Associated Virus Expressed in E. colip. 485
Extracellular Aspartic Proteinases from Candida Yeastsp. 489
Tyrosine 75 on the Flap Contributes to Enhance Catalytic Efficiency of a Fungal Aspartic Proteinase, Mucor pusillus Pepsinp. 501
Aspartic Proteinases from the Human Malaria Parasite Plasmodium falciparump. 511
Yeast and Mammalian Basic Residue-Specific Aspartic Proteases in Prohormone Conversionp. 519
Pepstatin-Insensitive Carboxyl Proteinasesp. 529
The Three-Dimensional X-Ray Crystal Structure of the Aspartic Proteinase Native to Trichoderma reesei Complexed with a Renin Inhibitor CP-80794p. 543
A Quantum Mechanical Model of the Hydration and Acidity of the Active Site in Aspartic Proteasesp. 549
Site-Directed Mutagenesis of Rhizopuspepsin: An Analysis of Unique Specificityp. 555
Site-Directed Mutagenesis Revealed Role of Subsite Residues of Mucor pusillus Pepsin in Catalytic Functionp. 559
A Novel Intracellular Acid Proteinase from the Plasmodia of a True Slime Mold, Physarum polycephalump. 565
Characteristics of YAP3, a New Prohormone Processing Aspartic Protease from S. cerevisiaep. 569
Candida albicans Aspartic Proteinase: cDNA Cloning and Comparison among Strainsp. 573
Molecular Cloning and Sequence Analysis of a Gene Encoding an Aspartic Proteinase from Aspergillus oryzaep. 577
Aspergillus niger var. macrosporus Proteinase B. cDNA Cloning, Expression, and Activation of the Proenzymep. 581
Expression and Secretion of Recombinant Aspartic Proteinases by Bacillus brevisp. 589
Expression of E. coli of Aspergillus niger var. macrosporus Proteinase A, a Non-Pepsin Type Acid Proteinasep. 597
X-Ray Crystallographic Study of a Non-Pepsin-Type Acid Proteinase, Aspergillus niger Proteinase Ap. 605
Conformation Analysis of Non-Pepsin-Type Acid Proteinase A from the Fungus Aspergillus niger by NMRp. 611
Author Indexp. 617
Subject Indexp. 621
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306448300
ISBN-10: 0306448300
Series: Advances in Experimental Medicine and Biology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 629
Published: 1995
Country of Publication: US
Dimensions (cm): 25.4 x 17.78  x 3.51
Weight (kg): 1.34

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