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Arterial Remodeling : A Critical Factor in Restenosis - Antoine Lafont

Arterial Remodeling

A Critical Factor in Restenosis

By: Antoine Lafont (Editor), Eric J. Topol (Editor)

Hardcover

Published: 31st October 1997
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Angioplasty has completely transformed the treatment of coronary artery disease and is widely used, with more than 800,000 procedures performed worldwide per year. However, the enthusiasm for angioplasty is shadowed by restenosis, which remains a critical problem after the procedure, resulting in clinical recurrence in over a third of patients. Recently, the mechanisms of restenosis have been completely reappraised with an enriched understanding that the original concept of neointimal hyperplasia may not be accounting for the bulk of the problem.
There is a desperate need to heighten understanding of the remodeling process at the molecular, cellular, and arterial level. Vascular remodeling is a well established concept in the field of atherosclerosis and hypertension, but only in recent years has its applicability to the field of restenosis become pivotal. Accordingly, the editors perceived the need to assemble the first book dedicated to the concept of coronary artery remodeling in restenosis, in order to clearly review the experiments leading to the remodeling hypothesis and integrate this with the neointimal hyperplasia (tumor) model for the development of the restenotic lesion.
The authors of this book present their experience to facilitate the understanding of the mechanisms for coronary restenosis and remodeling. The various experimental models, clinical issues, and basic mechanisms are reviewed in detail, resulting in a fresh approach to a vexing clinical problem. Arterial Remodeling: A Critical Factor in Restenosis will be useful to the physician and trainee who have an interest in restenosis, and specifically in the major pathophysiologic process which determines the fate of arterial healing in patients following percutaneous coronary revascularization. It is hoped that this book will lay the foundation for more effective therapies that will reduce the chance of constrictive remodeling and improve the long-term efficacy of non-surgical coronary revascularization in the future.

Preface
Foreword
Basis of the Concept
Restenosis: Prevention of a Complete Stabilizing Remodeling Response Following Direct Interventions on Plaques
Constrictive Remodeling: Do Concepts of Remodeling During Chronic Hypertension Apply to Restenosis?
Growth and Remodeling of Coronary Collateral Vessels
Restenosis and Remodeling: The Facts
Experimental Evidence of Remodeling After Angioplasty
Remodeling: Accelerator or Decelerator of Luminal Narrowing in Human Atherosclerotic Arteries
Histologic Basis of Vessel Remodeling After Various Interventional Procedures: A Comparison of Acute (Cracks, Breaks, Tears, Stretching) and Chronic (Tissue Proliferation, Recoil) Changes
Serial Intravascular Ultrasound Evidence for Arterial Remodeling as a Mechanism of Restenosis Following Interventional Coronary Procedures
Coronary Blood Flow During Interventional Procedures: Implications for Vascular Remodeling
Restenosis and Remodeling: The Targets Revisited
Restenosis and Remodeling: Is the Adventitia Involved?
Post-Angioplasty Smooth Muscle Cell Apoptosis
Intimal Hyperplasia is the Wrong Target: Restenosis as a Failure of Remodeling
Endothelial Dysfunction After Angioplasty: A Pathway for Remodeling?
Molecular Aspects of Remodeling
Vascular Remodeling and Lesion Formation in Restenosis: Implications for Nitric Oxide-Based Therapeutics
Oxidative Stress and Vascular Remodeling
Matrix Metalloproteinases in Injured Artery
Influence of Angioplasty on Matrix Signalling and Metabolism:
Intimal Lesion Growth: An Assessment of Important Cellular Events
The Effects of Oxidized Lipids and Lipoproteins on Arterial Growth, Remodeling and Restenosis
Oncogenes after Angioplasty
Potential Mechanisms
Blood Flow, Shear Stress and Remodeling of the Artery Wall
Inflammatory Mechanisms of Remodeling in Injured Arteries
Effect of Tensile Stress in Vascular Remodeling
Remodeling: Therapeutic Aspects
Coronary Remodeling and Interventional Strategies
Stent: A Mechanical Approach for Remodeling Inhibition
Pharmacologic Perspectives of Remodeling Inhibition
Gene Polymorphism and Restenosis
Gene Transfer and Vascular Remodeling
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780792380085
ISBN-10: 0792380088
Series: Developments in Cardiovascular Medicine
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 569
Published: 31st October 1997
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 3.18
Weight (kg): 2.24