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ARF Family GTPases : Proteins and Cell Regulation - Richard A. Kahn

ARF Family GTPases

Proteins and Cell Regulation

By: Richard A. Kahn (Editor)

Hardcover Published: 29th February 2004
ISBN: 9781402017193
Number Of Pages: 350

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For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.

From the reviews:

"A journey into a deeper understanding of the diversity of cellular controls exerted by the ARF family. The writing is so clear and well developed ... it will allow newcomers in the area to dive into a dynamic area of molecular and cellular science. ... the reader is treated to a wealth of discussion and critique on how ARFs modulate processes such as membrane fusion, vesicular transport, cell migration and receptor activity. This is an outstanding text for everyone with an interest in cell biology." (M. Thompson, Cell Biochemistry and Function, Vol. 23 (4), 2005)

Preface: The Arf Family Gtpasesp. vii
List of Contributorsp. xxv
The Arf Family Treep. 1
The GDP/GTP Cycle of Arf Proteinsp. 23
Arf and Phospholipidsp. 49
The Sec7 Family of Arf Guanine Nucleotide Exchange Factorsp. 71
Large Arf GEFs of the Golgi Complexp. 101
BIG1 and BIG2: Brefeldin A-Inhibited Exchange Factors for Arfsp. 121
Arf GTPase-Activating Protein 1p. 137
GIT Proteins: Arf Gaps and Signaling Scaffoldsp. 159
Paxillin-Associated Arf Gapsp. 185
Activation of Cholera Toxin and E. Coli Heat-Labile Enterotoxin (LT) by Arfp. 209
Phospholipase D, Arfaptins and Arfophilinp. 223
Coat Proteinsp. 241
Heterotetrameric Coat Protein-Arf Interactionsp. 259
Arf6p. 283
A Role for Arf6 in G Protein-Coupled Receptor Desensitizationp. 305
Arf-Like Proteinsp. 325
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9781402017193
ISBN-10: 1402017197
Series: Proteins and Cell Regulation
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 350
Published: 29th February 2004
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 24.0 x 16.0  x 1.91
Weight (kg): 0.82

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