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Apoptosis Genes - James J. Wilson

Apoptosis Genes

By: James J. Wilson (Editor), Catherine Booth (Editor), Christopher S. Potten (Editor)

Hardcover Published: 31st January 1999
ISBN: 9780412838606
Number Of Pages: 310

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Apoptosis, or programmed cell death, is a natural process by which damaged or unwanted cells are dismantled in an orderly and atraumatic fashion. It is of critical importance in development, homeostasis, and cell population control. Recent research is now enabling scientists to comprehend how genes and their protein products interact to control apoptosis. This has led to the position where researchers may be able to directly modify the action of key proteins through gene therapy and antisense oligonucleotides. This text presents an overview of the key genes involved in the control of apoptosis, together with thoughts on future prospects and clinical applications. The volume deals specifically with the regulation of apoptosis. Given the increased interest in the role of apoptosis genes in disease processes, this work should be useful to researchers investigating cancer, autoimmune disease, viral infection, cardiovascular disease, neurodegenerative disorders, AIDS, osteoporosis, and ageing.

List of Contributors
Introductionp. 1
The role of p53 in apoptosisp. 5
Mammalian bcl-2 family genesp. 37
Stress-responsive signal transduction: emerging concepts and biological significancep. 85
Control of Apoptosis Through Gene Regulationp. 119
Adhesion and Apoptosisp. 143
Death signalling in C. elegans and activation mechanisms of caspasesp. 167
Apoptosis in Drosophilap. 205
Viral genes that modulate apoptosisp. 243
Therapeutic manipulation of apoptosis in cancer and neurological diseasep. 281
Indexp. 304
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780412838606
ISBN-10: 0412838605
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 310
Published: 31st January 1999
Publisher: Chapman and Hall
Country of Publication: GB
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 1.39