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Apoptosis : The Life and Death of Cells - Christopher S. Potten

Apoptosis

The Life and Death of Cells

Paperback Published: 1st July 2004
ISBN: 9780521626798
Number Of Pages: 228

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The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between the digits to produce fingers and toes. Apoptosis is also necessary to destroy cells that represent a threat to the integrity of the organism, for example cells infected by a virus. In many cancers the genes regulating apoptosis are defective, producing immortal, continuously proliferating cells. This book discusses the philosophical and technical difficulties in defining the moment of death for a cell, as well as the biological implications and significance of programmed cell death. Recent developments in the genetic control and interacting gene networks associated with apoptosis are presented. The book is written for advanced undergraduate and postgraduate students, and is highly illustrated to aid understanding.

'A compelling read for anyone interested in organismal development ... This is a timely publication and one that will fill a much-needed niche on biologist's bookshelves.' Biologist
"[A] careful, thorough, user-friendly volume on programmed cell death." S.K. Sommers Smith, Boston University, CHOICE
"This is an important addition to any scientific library encomposing oncology or an biomedical fild needing a basic, yet complex collection of information on apoptosis and its influence on the lifetimes of most cellular organisms." Biology Digest

Prefacep. xi
Acknowledgments and dedicationsp. xv
Dead or alivep. 1
Movementp. 1
Metabolismp. 2
Sensory perceptionp. 3
Reproductionp. 3
Cell death: human analogiesp. 7
How to diep. 15
The undeadp. 15
The clearly deadp. 17
Necrosisp. 18
Apoptosisp. 20
Situations where death might be initiatedp. 23
How long to die?p. 28
Occurrence of apoptosisp. 29
What's in a name? A rose is a rose ...p. 33
Mitotic deathp. 36
Apoptosis versus necrosisp. 37
DNA degradationp. 38
How do we recognise apoptosis?p. 42
Assessment of DNA fragmentationp. 43
Assessment of protease activity in apoptosisp. 49
Changes in apoptosis-regulatory proteinsp. 52
Membrane changesp. 54
Morphologyp. 56
Cell death in cell culturesp. 57
What to wear and who clears up the rubbish?p. 61
To reproduce or die?p. 67
Defining our termsp. 67
DNA replicationp. 69
Cell divisionp. 71
How do we recognise a proliferating cell?p. 75
Recognition of cells replicating their DNAp. 77
Cell cycle quiescencep. 84
Cyclinsp. 86
Flow cytometry techniquesp. 88
The judge, the jury, and the executioner - the genes that control cell deathp. 91
p53 - The guardian of the genome in embryos and adultsp. 91
Genes that determine survival or death - the bcl-2 familyp. 98
Apoptotic proteasesp. 103
The big picturep. 107
Stem cellsp. 115
What is a stem cell?p. 115
Stem cell definitionp. 120
Stem cells and tissue injuryp. 124
Self-maintenance probabilityp. 126
A test of functional competence for stem cells: clonogenic cellsp. 126
Are stem cells intrinsically different from transit cells?p. 129
Differentiation options: pluripotencyp. 130
An in vivo system to study apoptosis: the small intestinep. 136
Proliferative organisation in the gutp. 136
Apoptosis in the gutp. 151
Apoptosis induced by other cytotoxics: are all cells programmed to die?p. 162
Apoptosis in the large bowel and the role of bcl-2p. 164
The adenomatous polyposis coli (APC) genep. 167
Small and large intestine cancer incidence figuresp. 169
Genome protection mechanismsp. 170
Cell death (apoptosis) in diverse systemsp. 184
Measuring the levels of cell death (apoptosis)p. 189
Indexp. 199
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780521626798
ISBN-10: 052162679X
Series: Developmental & Cell Biology
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 228
Published: 1st July 2004
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 24.13 x 17.78  x 1.27
Weight (kg): 0.5

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