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Apoptosis and Inflammation : Progress in Inflammation Research :  Progress in Inflammation Research - James Winkler

Apoptosis and Inflammation : Progress in Inflammation Research

Progress in Inflammation Research

By: James Winkler (Editor)

Hardcover Published: July 1999
ISBN: 9783764357955
Number Of Pages: 244

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Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. However, many disease conditions utilize apoptosis for pathological ends, resulting in inappropriate cell death and tissue destruction. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases.

List of contributors
Introduction - Apoptosis in inflammatory cells and diseasesp. 1
Signaling cascades of apoptosisp. 7
Influence of arachidonic acid metabolism on cell proliferation and apoptosisp. 19
Apoptosis in the regulation of and function of T and B lymphocytes in inflammationp. 39
Granulocytesp. 53
Hematopoietic cellsp. 85
Chondrocyte apoptosisp. 101
Keratinocytesp. 121
Apoptosis in rheumatoid arthritisp. 149
Apoptosis and inflammatory disease: osteoarthritisp. 163
Lupus and lupus-like syndromesp. 181
Psoriasis and apoptosis: A fundamental analysis of the psoriatic phenotype with clinical and therapeutic correlationsp. 213
Apoptosis in renal diseasep. 227
Indexp. 239
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783764357955
ISBN-10: 3764357959
Series: Progress in Inflammation Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 244
Published: July 1999
Publisher: SPRINGER VERLAG GMBH
Country of Publication: CH
Dimensions (cm): 23.39 x 15.6  x 1.6
Weight (kg): 0.54