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Aplastic Anemia : Pathophysiology and Treatment - Hubert Schrezenmeier

Aplastic Anemia

Pathophysiology and Treatment

By: Hubert Schrezenmeier (Editor), Andrea Bacigalupo (Editor)

Hardcover Published: 11th November 1999
ISBN: 9780521641012
Number Of Pages: 403

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This book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. As well as providing a detailed overview of the pathophysiology of the disease, the international team of authors covers all aspects of management, including the established approaches of bone marrow transplantation and immunosuppressive treatment, new approaches such as the use of hematopoietic growth factors and escalated immunosuppression, and controversial issues such as stem cell transplantation. Also included is an important international consensus document on treatment, and a final section concentrates on the inherited syndrome Fanconi's anemia. Detailed treatment guidelines are given, making this the definitive resource for hematologists and other clinicians involved in the management and supportive care of patients with aplastic anemia. Scientists interested in bone marrow failure will also find this an invaluable reference.

'This book provide a comprehensive and up to date concepts on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. The book is an excellent and enjoyable to read. The amateur who is satisfied with certainty will drive more from it than the impartial professional seeking and challenge. For the mahority of doctors and especially human hematologists, the book succeeds as an example of the precept 'first do not harm'. Aplastic Anemia is a super textbook and should be in the library of every scientist interested in this subject. I would also suggest the book to medical students.' Professor Pio Conti Aplastic Anemia is a super textbook and should be in the library of every scientist interested in this subject. I would also suggest the book to medical students.' Professor Pio Conti, International Journal of Immunopathology and Pharmacology Aplastic Anemia will be a useful reference work for clinicians who deal with this disorder and will be a good source of background information for those conducting basic research on the mechanisms.' Journal of the Royal Society of Medicine 'This reference is now the most up-to-date specialized reference on this subject. It will be of interest to and should be read by trainees in both pediatric and adult hematology and oncology.' Doody's Health Sciences Book Review Journal 'Aplastic anemia (AA) is a rare, complex, and often fatal disease that with appropriate therpy today has a high cure rate. This book is an excellent review of this disease with special emphasis on the different therapeutic modalities. It is a must read for all fellows in hematology/oncology, as well as other physicians taking care of patients with AA or Fanconi's anemia. It is also an important resource of information and will serve as a reference manual well into the new century.' Brynjar Vidarsson, Oncology/Karger 'The book is up to date, and gives clear information on pathogenesis ... this book is highly recommended and will remain valuable for many years to come.' Jill Hows, Hematological Oncology

Pathophysiology of Acquired Aplastic Anemia
Stem cell defect in aplastic anemia
Cytokine abnormalities in aplastic anemia
Role of T-lymphocytes and apoptosis in pathophysiology of aplastic anemia
Role of apoptosis in pathophysiology of aplastic anemia
Interrelation between aplastic anemia and paroxysmal nocturnal hemoglobinuria
Aplastic anemia and other clonal disorders
Epidemiology and Clinical Features of Acquired Aplastic Anemia
Epidemiology and etiology of aplastic anemia
Clinical presentation, natural course and prognostic factors
Treatment of Acquired Aplastic Anemia
Supportive treatment of patients with severe aplastic anemia
Immunosuppressive treatment of aplastic anemia
Role of cytokines in the treatment of aplastic anemia
HLA-identical sibling bone marrow transplantation to treat severe aplastic anemia
Alternative donor bone marrow transplantation for severe acquired aplastic anemia
Treatment of children with acquired aplastic anemia
Long-term follow up of patients with aplastic anemia
Guidelines for treatment of aplastic anemia (international consensus document)
Fanconi's Anemia
Clinical features and diagnosis of Fanconi's anemia
Genetic basis of Fanconi's anemia
Treatment of Fanconi's anemia
Genetic correction of Fanconi's anemia
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521641012
ISBN-10: 0521641012
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 403
Published: 11th November 1999
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 26.04 x 19.68  x 2.54
Weight (kg): 1.09