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Antisense Research and Applications - Stanley T. Crooke

Antisense Research and Applications

Hardcover Published: 27th May 1993
ISBN: 9780849347054
Number Of Pages: 624

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Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications.
In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs.
This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.

Basic Principles of Antisense Therapeuticsp. 1
Antisense Medicinal Chemistryp. 51
In Vitro Cellular Uptake, Distribution, and Metabolism of Oligonucleotidesp. 103
Pharmacokinetic Properties of Phosphorothioates in Animals - Absorption, Distribution, Metabolism and Eliminationp. 141
Toxicity of Oligodeoxynucleotide Therapeutic Agentsp. 169
Pharmacokinetic Properties of Phosphorothioate Oligonucleotides in Humansp. 217
Safety and Tolerance of Phosphorothioates in Humansp. 233
Immune Stimulation by Oligonucleotidesp. 243
Pharmacological Inhibition of Dopaminergic and Other Neurotransmitter Receptors Using Antisense Oligodeoxynucleotidesp. 263
Pharmacological Effects of Antisense Oligonucleotide Inhibition of Immediate-Early Response Genes in the CNSp. 309
Inhibition of G Proteins by Antisense Drugsp. 341
Use of Antisense Oligonucleotides to Modify Inflammatory Processesp. 371
Antisense Oligonucleotides and Their Anticancer Activitiesp. 395
Pharmacological Activity of Antisense Oligonucleotides in Animal Models of Diseasep. 427
Clincial Antiviral Activitiesp. 445
Antisense Oligonucleotides to Protein Kinase C-[alpha] and C-raf Kinase: Rationale and Clinical Experience in Patients with Solid Tumorsp. 463
Nucleic Acid Therapeutics for Human Leukemia: Development and Early Clinical Experience with Oligodeoxynucleotides Directed at c-mybp. 477
Properties of ISIS 2302, an Inhibitor of Intercellular Adhesion Molecule-1, Humansp. 499
Pharmacokinetics and Bioavailability of Antisense Oligonucleotides Following Oral and Colorectal Administrations in Experimental Animalsp. 525
Antisense Properties of Peptide Nucleic Acidp. 545
Triple Helix Strategies and Progressp. 561
Subject Indexp. 611
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780849347054
ISBN-10: 084934705X
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 624
Published: 27th May 1993
Publisher: CRC PR INC
Country of Publication: US
Dimensions (cm): 26.67 x 19.05  x 3.81
Weight (kg): 1.36
Edition Number: 1

Earn 1912 Qantas Points
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