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Anticancer Drug Discovery and Development: Natural Products and New Molecular Models : Proceedings of the Second Drug Discovery and Development Symposium Traverse City, Michigan, USA - June 27-29, 1991 - Frederick A. Valeriote

Anticancer Drug Discovery and Development: Natural Products and New Molecular Models

Proceedings of the Second Drug Discovery and Development Symposium Traverse City, Michigan, USA - June 27-29, 1991

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Published: 31st July 1994
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With the publication of these proceedings from the Second Drug Discovery and Development Symposium, this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer. This Second Symposium emphasized the types of materials being discovered and their therapeutic activity. This is especially evident in the natural product discovery programs, where unique and active structures are being identified.
The major contributors to the meeting were the investigators participating in the National Cooperative (Natural Products) Drug Discovery Groups [NC(NP)DDG]. These groups reflect an association among researchers at universities or cancer centers, pharmaceutical companies and the National Cancer Institute. Their sources of materials are varied, reflecting chemical inventories of pharmaceutical companies, organic synthetic compounds from the laboratory, cytotoxics as well as biologics and their hybrids, and natural products obtained from plants, marine organisms and microorganisms. The models employed in the discovery systems vary from broadly cellular based to specific enzymes to defined cellular functions. Each of them is believed important to the malignant state and will allow for the discovery of compounds which will have efficacy in cancer therapy.
The goal of the participants is both to discover new anticancer agents and to develop them as efficiently as possible into clinically useful additions to treatment. Of importance is the fact that there are a number of promising leads which will soon be moving into the clinic thereby testing the effectiveness of this NC (NP) DDG approach.

Discovery of Natural Products from Microalgae and Marine Organismsp. 1
Discovery of Naturally Occurring Antitumor Agentsp. 27
Marine Invertebrates and Microbes as Sources of Potential Antitumor Compoundsp. 39
Novel Strategies for the Discovery of Plant-Derived Anticancer Agentsp. 63
A Strategy for Identifying Novel Inhibitors of DNA Topoisomerase Ip. 85
Altromycins: A New Family of Antitumor Antibiotics - Discovery and Biological Evaluationp. 95
Suppression of Human Melanoma Metastasis in SCID Mice with Antibodies to the EGF-Receptorp. 119
Growth Factor and Oncogene Signalling as a Target for Anticancer Drug Developmentp. 127
Nucleoside and Nucleotide Modulation of Oncogenic Expression: A New Approach to Cancer Chemotherapyp. 149
Interferons in Cancer Therapy: From Clinical Trials to New Potentials in Anticancer Drug Discovery and Developmentp. 183
Selection and Manipulation of Immunoglobulins for Radionuclide Deliveryp. 209
Microorganisms: Strategic Sources of Novel Anti-Tumor Agentsp. 235
The Therapeutic Potential of Novel Pure Antiestrogensp. 269
Preclinical Pharmacology and Phase I Clinical Trials of Taxotere (RP 56976, NSC 628503)p. 283
Bropirimine, a Small-Molecule Biological Response Modifier and an Effective Antitumor Agentp. 299
Determinants of Etoposide Cytotoxicity in Vitrop. 347
Screening for Anticancer Leads from Marine Organisms in a Mechanism-Based Drug Discovery Programp. 365
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792329282
ISBN-10: 0792329287
Series: Developments in Oncology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 403
Published: 31st July 1994
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 24.13 x 16.51  x 2.54
Weight (kg): 0.89