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Antibodies : Volume 2: Novel Technologies and Therapeutic Use - G. Subramanian

Antibodies

Volume 2: Novel Technologies and Therapeutic Use

By: G. Subramanian (Editor)

Hardcover Published: 31st March 2004
ISBN: 9780306483158
Number Of Pages: 232

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If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an overview of the current advances applied in the manufacture of monoclonal antibody including:
-concepts in development of manufacturing strategies,
-importance of antibody fragments,
-application of chromatography method development,
-quality control,
-effect of expression on antibody properties,
-virus removal and safety,
-pharmacokinetics,
-regulatory aspects.

Antibodies Volume 1: Production and Purification together with Volume 2: Novel Technologies and Therapeutic Use will be of great value to all of those who are actively working in the field of antibodies.
Volume 2: Novel Technologies and Therapeutic Use brings to the forefront current advances in novel technologies for the manufacturing of monoclonal antibodies and also their extensive clinical importance. Following on from Antibodies Volume 1: Production and Purification, this volume concentrates on:
-new technologies in the manufacture of monoclonal antibodies,
-the application of antibodies in cancer therapy and functional genomic therapy,
-the importance of antibodies and prospects of antibody engineering for the future.

Transgenic technology for monoclonal antibody productionp. 1
Generation, engineering and production of human antibodies using HuCALp. 13
Achieving appropriate glycosylation during the scaleup of antibody productionp. 53
Approaches to devise antibody purification processes by chromatographyp. 79
Novel HIV neutralizing antibodies selected from phage display librariesp. 105
Monoclonal and bispecific antibodies in combination with radiotherapy for cancer treatmentp. 119
Antibodies, a potent tool to target genes into designated cells and tissuesp. 141
Intrabodies: development and application in functional genomics and therapyp. 157
Expression of recombinant antibodies by tumour cells: on road to anti-tumour therapyp. 169
Antitumor antibodies: from research to clinicp. 183
Macrophages for immunotherapyp. 189
Future prospects in antibody engineering and therapyp. 199
Indexp. 217
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306483158
ISBN-10: 0306483157
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 232
Published: 31st March 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 0.59