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Antibodies : Volume 1: Production and Purification - G. Subramanian


Volume 1: Production and Purification

By: G. Subramanian (Editor)

Hardcover Published: 31st March 2004
ISBN: 9780306482458
Number Of Pages: 314

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If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an overview of the current advances applied in the manufacture of monoclonal antibody including:
-concepts in development of manufacturing strategies,
-importance of antibody fragments,
-application of chromatography method development,
-quality control,
-effect of expression on antibody properties,
-virus removal and safety,
-regulatory aspects.

Antibodies Volume 1: Production and Purification together with Volume 2: Novel Technologies and Therapeutic Use will be of great value to all of those who are actively working in the field of antibodies.
Volume 2: Novel Technologies and Therapeutic Use brings to the forefront current advances in novel technologies for the manufacturing of monoclonal antibodies and also their extensive clinical importance. Following on from Antibodies Volume 1: Production and Purification, this volume concentrates on:
-new technologies in the manufacture of monoclonal antibodies,
-the application of antibodies in cancer therapy and functional genomic therapy,
-the importance of antibodies and prospects of antibody engineering for the future.

Concepts in Development of Manufacturing Strategies for Monoclonal Antibodies
Antibody Fragments: Production, Purification and Formatting for Therapeutic Applications
Large Scale Production of Therapeutic Antibodies: Considerations for Optimizing Product Capture and Purification
Scale-Up of Antibody Purification. From Laboratory Scale to Production
Purification of Antibody by Chromatographic Methods
Quality Control of Antibodies for Human Use
Expression of Human Anti Rh(D) Monoclonal Antibodies into Different Cell lines: Influence on their Functional Properties
Monoclonal Antibody Production: Minimising Virus Safety Issues
Contract Manufacturing of Biopharmaceutical Grade Antibodies
The Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies
Regulatory and Legal Requirements for the Manufacture of Antibodies
Transgenic technology for monoclonal antibody production
Generation, engineering and production of human antibodies using HuCAL
Achieving appropriate glycosylation during the scaleup of antibody production
Approaches to devise antibody purification processes by chromatography
Novel HIV neutralizing antibodies selected from phage display libraries
Monoclonal and bispecific antibodies in combination with radiotherapy for cancer treatment
Antibodies, a potent tool to target genes into designated cells and tissues
Intrabodies: development and application in functional genomics and therapy
Expression of recombinant antibodies by tumour cells: on road to anti-tumour therapy
Antitumor antibodies: from research to clinic
Macrophages for immunotherapy
Future prospects in antibody engineering and therapy
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780306482458
ISBN-10: 0306482452
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 314
Published: 31st March 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 0.63