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Antibiotic Associated Diarrhoea and Colitis : The role of Clostridium difficile in gastrointestinal disorders - S.Peter Borriello

Antibiotic Associated Diarrhoea and Colitis

The role of Clostridium difficile in gastrointestinal disorders

By: S.Peter Borriello (Editor)

Hardcover Published: 31st January 1984
ISBN: 9780898386233
Number Of Pages: 180

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Antimicrobial-associated diarrhea is often caused by Clostridium difficile; this disease can best be diagnosed by detection of fecal cytotoxin in a tissue culture assay and, when therapy is indicated, can be effectively treated with orally administered vancomycin. The cause of disease in most cases of antimicrobial-associated diarrhea that do not involve C. difficile is not known; fortunately, this form of diarrhea 1S usually mild. Antimicrobial-associated diarrhea may also rarely involve s. aureus and certain enteric pathogens. 37 QHAPTER 4 Qf. TECTlON. ISOLATION Al:iQ...IQENTlFICATlON OF CLOSTRIDIUM PIFFICILE S. P. BORRIELLO and PAULINE HONOUR Introduction 38 Detection of Co dlfflcile in stools 38 Direct methods 38 Indirect methods 39 Isolation of Co djfficjle 40 Identification of Co difflcile 44 38 DETECTION ISOLATION AND IDENTIFICATION OF CLOSTRIDIUM DIFFICILE S. P. Borriello and Pauline Honour Introduction In view of the mounting evidence generated world wide in the last few years that firmly implicates GBP. difficile as the aetiological agent in both antibiotic and non-antibiotic associated pseudomembranous colitis (Larson ~ al. , 1978, Bartlett ~ al. , 1978a, George ~ al. , 1978a), and also recent recognition of the fact that there may be a spectrum of gastrointestinal diseases associated with GBP. difficile infections (Borriello and Larson, 1981, Bolton ~ al. , 1980, Brettle ~ al. , 1982), an increasing number of laboratories are seeking to detect, isolate and identify GBP. difficile from clinical samples.

1 Antibiotics associated with Clostridium difficile mediated diarrhoea and/or colitis.- 2 Spectrum of disease.- 3 Diagnosis and treatment of antimicrobial agent-associated diarrhea and colitis.- 4 Detection, isolation and identification of Clostridium difficile.- 5 Detection of Clostridium difficile toxins.- 6 Epidemiology of antimicrobial agent-associated diarrhea and colitis.- 7 Typing Clostridium difficile.- 8 Clostridium difficile and colonization resistance.- 9 Characteristics of the toxins of Clostridium difficile.- 10 Interaction of Clostridium difficile toxin B (cytotoxin) with cultured cells.- 11 Animal models of Clostridium difficile infection.- 12 The pathology of antibiotic-associated colitis.- Concluding remarks The unanswered questions.- Reference section.

ISBN: 9780898386233
ISBN-10: 0898386233
Series: Developments in Gastroenterology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 180
Published: 31st January 1984
Publisher: Kluwer Academic Publishers
Country of Publication: US
Dimensions (cm): 25.4 x 17.15  x 1.27
Weight (kg): 0.54