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Annual Reports in Medicinal Chemistry Volume 40 : Volume 40 - Annette Doherty

Annual Reports in Medicinal Chemistry Volume 40

Volume 40

Paperback Published: 1st December 2005
ISBN: 9780120405404
Number Of Pages: 558

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Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market.
* Critical reviews of the previous year's literature in many topics of interest to medicinal chemists
* Highlights major developments in medicinal chemistry
* Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes

Industry Reviews

Praise for the Series
"This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development."
"This book is strongly recommended for researchers, teachers, students, administrators-in short, anyone whose interests impinge on medicinal chemistry. In view of the work's documented reference value, it is a must for inclusion in the scientist's personal library."
"All topics are covered in sufficient depth, with extensive references, to allow either the specialist or the novice to be informed of the latest developments in a particular area of medicinal chemistry."

Contributorsp. xi
Prefacep. xiii
Corrigendump. xv
Central Nervous System Diseases
Neuronal Nicotinic Acetylcholine Receptor Modulators: Recent Advances and Therapeutic Potentialp. 3
Recent Advances in Selective Serotonergic Agentsp. 17
BACE Inhibitors for the Treatment of Alzheimer's Diseasep. 35
Positron Emission Tomography Agents for Central Nervous System Drug Development Applicationsp. 49
Cardiovascular and Metabolic Diseases
Emerging Topics in Atherosclerosis: HDL Raising Therapiesp. 71
Small Molecule Anticoagulant/Antithrombotic Agentsp. 85
CB1 Cannabinoid Receptor Antagonistsp. 103
Melanin-Concentrating Hormone as a Therapeutic Targetp. 119
Glycogen Synthase Kinase-3 (GSK-3): A Kinase with Exceptional Therapeutic Potentialp. 135
Inhibitors of Dipeptidyl Peptidase 4p. 149
Recent Advances in Therapeutic Approaches to Type 2 Diabetesp. 167
Inflammatory, Pulmonary, and Gastrointestinal Diseases
The TRPV1 Vanilloid Receptor: A Target for Therapeutic Interventionp. 185
Leukotriene Biosynthesis Inhibitorsp. 199
CXCR3 Antagonistsp. 215
PDE7 Inhibitors: Chemistry and Potential Therapeutic Utilitiesp. 227
Cancer and Infectious Diseases
Inhibitors of Anti-apoptotic Proteins for Cancer Therapyp. 245
AKT Kinase and Hsp90 Inhibitors as Novel Anti-cancer Therapeuticsp. 263
Novel Strategies in HIV Prevention - Development of Topical Microbicidesp. 277
New Developments in HIV Therapeuticsp. 291
Antibacterials for the Treatment of Gram Positive Infectionsp. 301
Progress on New Therapeutics for Fungal Nail Infectionsp. 323
Topics in Biology
Chemical Tools for Indications Discoveryp. 339
Structural Genomics and Drug Discoveryp. 349
Topics in Drug Design and Discovery
G-Protein Coupled Receptor Inverse Agonists: Identification, Pharmacological Relevance and Functional Assaysp. 373
The Utility of Metabonomics for Drug Safety Assessmentp. 387
Computational Prediction of Blood-brain Barrier Permeationp. 403
Pharmacogenetics and Drug Developmentp. 417
Trends and Perspectives
Trends in Pharmaceutical Innovationp. 431
To Market, To Market-2004p. 443
Compound Name, Code Number and Subject Index, Volume 40p. 475
Cumulative Chapter Titles Keyword Index, Volumes 1-40p. 485
Cumulative NCE Introduction Index, 1983-2004p. 503
Cumulative NCE Introduction Index, 1983-2004, by Indicationp. 521
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780120405404
ISBN-10: 0120405407
Series: Annual Reports in Medicinal Chemistry : Book 40
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 558
Published: 1st December 2005
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 23.5 x 16.5  x 2.59
Weight (kg): 0.84

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