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Animal Cell Technology : Challenges for the 21st Century :  Challenges for the 21st Century - K. Ikura

Animal Cell Technology : Challenges for the 21st Century

Challenges for the 21st Century

By: K. Ikura (Editor), Masaya Nagao (Editor), Seiji Masuda (Editor), R. Sasaki (Editor)

Hardcover Published: August 1999
ISBN: 9780792358053
Number Of Pages: 452

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Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviors of differentiated animal cells but also to ascertain their abilities to be used in industrial and medical purposes. The goal of animal cell technology includes accomplishments of clonal expansion of differentiated cells with useful ability, optimization of their culture conditions, modulation of their ability to produce medically and pharmaceutically, important proteins, and the application of animal cells to gene therapy and artificial organs. This volume gives the readers a complete review of present state of the art in Japan. The Proceedings will be useful for cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers and other disciplines related to animal cell culture, working in either academic environments or in biotechnology and pharmaceutical industries.

Preface
The role of Hong Kong SAR in the development of biotechnology industry in Chinap. 1
Increase in intracellular calcium influx enhances monoclonal antibody productivityp. 5
Energy metabolism and antibody production based on flux analysis in hybridomap. 11
Transient transfection induces early cytosolic calcium signaling in CHO-K1 cellsp. 17
An on-line feeding strategy for fed-batch and dialysis cultures of hybridoma cellsp. 23
Effects of serum and other medium components on suspension culture of CHO cells producing tissue plasminogen activatorp. 29
Effects of osmotic pressure on metabolism of CHO cells producing tissue plasminogen activator in adhesion culture compared with that in suspension culturep. 33
Cultivation of CHO cells on novel microcarriersp. 39
Bleeding strategy for the long-term perfusion culture of hybridomap. 45
Metabolic flux distributions in hybridoma cells at different metabolic statesp. 51
On-line detection of metabolic demand and changes to it: heat flux in continuous cultures of animal cellsp. 57
Growth stimulation of CHO cells by phospholipids in serum-free culturep. 63
A kinetic model of macromolecular metabolism in batch and fed-batch cultures of hybridoma cells producing monoclonal antibodyp. 69
Enhancement of antibody productivity in the near-zero specific growth rate during glucose and glutamine-limited fed-batch culture of hybridoma cellsp. 75
Long-term culture of CHO cells on porous microcarriers in a stirred tank equipped with a modified cell retention systemp. 81
Continuous production and recovery of recombinant Ca[superscript ++] binding receptor from HEK 293 cells using perfusion through a packed bed bioreactorp. 87
Characterization of recombinant bovine lactoperoxidase produced by CHO cellsp. 93
Expression of a soluble [alpha][beta] heterodimeric T cell receptor in animal cellsp. 99
Posttranslational modifications of recombinant von Willebrand factor: Limitations and experimental improvement at high yield expressionp. 105
Incubation with heparin as an improved harvest method for high titre Disabled Infectious Single Cycle (DISC) HSV-2 from microcarrier culturesp. 111
Passaging of microcarrier cultures as an alternative method for the seeding of large scale bioreactors for the production of high titre Disabled Infectious Single Cycle HSV-2 vaccine (DISC HSV)p. 117
The hybrid system using both promoter activation and gene amplification for establishment of exogenous protein hyper-producing cell linesp. 123
System for large scale protein expression in Bombyx morip. 129
Protein-free culture of ras-amplified recombinant BHK-21 cellsp. 133
Effect of sugar composition on the heterogeneity of antibody in hybridoma cultivationp. 139
Modulation of antigen binding of human antibody via a glycosylation by hybridoma culture with various carbon sourcesp. 145
Manipulation of cytokine production from CD8[superscript +] T cells by means of amino acid-substituted analogs of a peptide antigenp. 149
A novel effect of nivalenol (NIV) on the immune response NIV, a trichothecene mycotoxin, selectively inhibits antigen-specific Th2 responsesp. 155
Human-human hybridomas producing monoclonal antibodies reactive to house dust mites antigenp. 161
Establishment of human-mouse hybridomas secreting antibodies to rice-allergensp. 167
Cell culture engineering using intelligent biomaterialsp. 171
Spatial development of mouse bone marrow cells cultivated in porous carriersp. 177
Tumor promoting mechanism of biomaterials: No involvement of mutation in cx43 gene in the tumorigenesis induced by polyurethanes in vitrop. 181
Xenotransplantation of cultured newborn pig thyroid tissue for the treatment of post-radioiodine hypothyroidism in ratsp. 187
Improved production of retroviral vectors under serum-free conditions for the application of gene therapyp. 193
Large scale production of rh-albumin expressed in the milk of transgenic cattle - An economic and technical challengep. 199
Transgenic rabbits: A novel model for the study of atherosclerosisp. 203
In vivo gene transfer to chicken via blastodermal cells of early developmental embryosp. 209
Overview of the international endeavor toward harmonization of technical requirements for the control of new medicines from biotechnologyp. 215
Reducing risks of animal origin contaminants in cell culturep. 221
Cytotoxicity testing for evaluating food safetyp. 227
Factors specifically expressed in osteoblastsp. 231
Osteoclast differentiation factor is a ligand for osteoprotegerin / osteoclastogenesis-inhibitory factorp. 243
Erythropoietin protects neurons from ischemic damagep. 249
Monovalent antigen activates antibody/cytokine receptor chimera and controls hematopoietic cell growthp. 255
Molecular cloning of the genes that determine the invasive activities of rat ascites hepatoma cellsp. 261
Antitumor protein (AP) from a mushroom induced apoptosis to transformed human keratinocyte by controlling the status of pRB, c-myc, cyclin E-CDK2, and p21[superscript WAF1] in the G1/S transitionp. 265
Transformation of NIH/3T3 and C3H/10T1/2 cells by citrinin and ochratoxin Ap. 273
Senescence induction in cancer cellsp. 279
Growth characteristics of NIH3T3 cells expressing bFGF and/or IGF-I and/or IGF-IIp. 283
Targeted disruption of a mitochondrial transcription factor A in the chicken DT40 cell linesp. 289
Expression and characterization of mouse epidermal transglutaminase in baculovirus-infected insect cellsp. 295
Effect of tea polyphenols on degranulation in human mature basophils differentiated with IL-4p. 301
Counteraction of the active form of vitamins A and D on up-regulation of adipocyte differentiation with PPAR[subscript [gamma]] ligand, a thiazolidinedione, in 3T3-L1 cellsp. 307
CCK regulation of monitor peptide gene expression in pancreatic acinar AR42J cellsp. 313
Detection of mitochondrial regulatory region RNA in cultured cells and differentiated tissue cells: The implications for cellular growth controlp. 319
Effect of ovarian steroids and oxytocin on local production of prostaglandin E[subscript 2], prostaglandin F[subscript 2[alpha]] and endothelin-1 in cow oviductal epithelial cell monolayersp. 325
TGF- [beta] induced cellular senescence in cancer cells is reversible and operates via two separate and independent pathwaysp. 331
Molecular cloning and characterization of specific genes involved in cellular senescencep. 337
Regulatory mechanisms of granulosa cell apoptosis in ovarian follicle atresiap. 343
Enhancement of Fc[epsilon]RI expression by hydrocortisone induces the upregulation of Fc[epsilon]RI[gamma] mRNA in the human leukemia cell line KU812p. 349
Telomere shortening in cancer cells by electrolyzed-reduced waterp. 355
Acetic acid suppresses the increase of glycosidase activity during culture of Caco-2 intestinal epithelial cellsp. 361
Effects of digested skim milk on the proliferation activity of human acute myeloid leulemia (HL-60) cellsp. 367
Differentiation-inducing activity of human leukemia cell lines by extracts of wild plants, seaweed and mushrooms in Akitap. 373
Anti-tumorigenic protein from Aralia elata: The induction of apoptosis in transformed cellsp. 379
Suppression of UV damage-induced apoptosis of human melanoma cells by a fermented milk, Kefirp. 385
Recognition system for dietary fatty acids in the rat small intestinal cells and taste budsp. 391
Effect of rose bengal on immunoglobulin production by mouse B lymphoma, WEHI-279 cellsp. 397
Class-specific regulation of immunoglobulin production by rose bengal in human B cell lines and peripheral blood lymphocytesp. 403
Inhibitory action of carotenoids in crab shell on the invasion of hepatoma cells co-cultured with mesothelial cellsp. 409
The neurite-initiating effect of microbial extracellular glycolipidsp. 415
Induction of basophilic and eosinophilic differentiation in the human leukemia cell line KU812p. 421
Mannosylerythritol lipid induced apoptosis and differentiation of melanoma B16 cellsp. 427
A non-radioactive in vitro bioassay for recombinant human IL-11p. 433
Establishment of assay system for immunoregulatory factors using whole cell culture of mouse splenocytesp. 439
Author Indexp. 445
Subject Indexp. 449
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792358053
ISBN-10: 0792358058
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 452
Published: August 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 2.54
Weight (kg): 0.84

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