| Preface | |
| Search for Edible Plant Constituents of Anti-Tumor Promotion Using an Inhibition Test of Epstein-Barr Virus Activation in Raji Cells | p. 1 |
| The Nature and Effect of Cell-Cell Interactions Between Recombinant CHO Cells Producing Human Interferon-Gamma | p. 9 |
| Characterization of Newly Established Cells Which Provide an Animal Model for Spontaneous Metastasis | p. 19 |
| Bovine Mammary Epithelial Cells: Morphology, Protein Synthesis and Gene Transfection | p. 25 |
| Growth and Differentiation of a Small Intestinal Epithelial Cell Line, IEC-6 | p. 33 |
| Subunit Assembly of Laminin Variants in Cultured Animal Cells | p. 41 |
| Regulation of Mitochondrial Gene Expression by Interferons | p. 49 |
| Production of the Human Growth Hormone in Serum-Free UC203 Medium | p. 57 |
| Stable Production of Pro-Urokinase and Its Derivative by Namalwa KJM-1 Cells Adapted to a Serum-Free Medium | p. 63 |
| Production and Characterization of Recombinant Soluble Form Erythropoietin Receptor | p. 71 |
| A ts-SV40 Based New Mammalian Plasmid Vector and Its Copy Number Control by Temperature Change | p. 79 |
| Selection of Regulatory Mutants of [mu] Gene Expression from Myeloma Cells Transfected with the Modified [mu] Gene | p. 85 |
| Process Control of BHK Cells by Nucleotide Pool Measurement | p. 93 |
| Purification and cDNA Cloning of Flatfish Interferon | p. 99 |
| Detection by Fluorescence in Situ Hybridization of the Erythropoietin Gene Introduced Into Animal Cells | p. 107 |
| High-Level Expression of Recombinant Bovine [beta]-Lactoglobulin in Insect Cells | p. 115 |
| Mass Production and Purification of Recombinant Flatfish Interferon | p. 123 |
| Stimulation of Protein Degradation by Tumor Necrosis Factor [alpha] in Cultured Muscle Cells | p. 129 |
| From In Vitro Cell Culture to In Vivo Animal Study: Demonstration that Epidermal Growth Factor (EGF) is a Potent Inhibitor of Adipose Differentiation | p. 135 |
| Co-Operative Action of Cysteine and Some Hormones on Bile Acid Synthesis in Primary Cultured Rat Hepatocytes | p. 143 |
| Suppression of Killer T Cell Induction by Prodigiosin 25-C | p. 149 |
| Immunopotentiator from Bifidobacterium Adolescentis | p. 155 |
| Immunosuppressive Properties of FK-506 | p. 165 |
| Enhancement of Antibody Production and Cell Proliferation by Marine Bioactive Substances | p. 171 |
| Effect of a Dialyzate of Spinach on the Chromosomal Aberration Induced by Mutagens in Cultured Chinese Hamster Cells | p. 177 |
| Suppression of Melanin Production in a Mouse B16 Melanoma 4A5 Cell Line by a Spinach Extract | p. 183 |
| Effect of Spinach Extracts on the Proliferation and on Some Phenotypic Characteristics of Human Myeloid Leukemia Cell Lines | p. 189 |
| Sustained Inducibility of Cytochrome P450 Activity in Rat Hepatocytes Cultured in a Serum-Free Medium | p. 195 |
| Biosynthesis of Protein Products by Animal Cells - Are Growth and Non-Growth Associated Concepts Valid or Useful? | p. 203 |
| Use of Liquid Medium Concentrates to Enhance Biological Productivity | p. 215 |
| Optimisation of [alpha]-Interferon Expression of Namalwa Cells | p. 223 |
| Changes in the Glycosylation of Interferon-[gamma] During Culture | p. 231 |
| Growth Control of Hybridoma Cultures by Adding or Depriving Interleukin-6, Caffeine, Amino Acids, Growth Factors, or Antisense C-myc | p. 237 |
| Chemostat Culture Studies on CHO Cells Producing Interferon-[gamma] | p. 243 |
| Chinese Hamster Ovary (CHO) Cell Growth and Recombinant Protein Production in Serum-Free Media | p. 251 |
| Mechanism of IL-10 Production by a CD8[superscript +]T Cell Clone | p. 259 |
| Generation of CHO Cell Mutants for Growth Control | p. 267 |
| Removability and Permeability of DNA in a Solution by Cuprammonium Regenerated Cellulose Hollow Fiber (BMM[superscript TM]) for Process Validation of Purification Process of Bio-Drugs | p. 273 |
| Principles and Methods of Process Validation Studies for Virus Removal and Inactivation | p. 281 |
| Combination of Virus Removal and Inactivation for the Process Validation of Bio-Drugs | p. 289 |
| A New, Validated Method for the Destruction of Conventional Viruses and Unconventional Infectious Agents (e.g. BSE and Scrapie) in Proteins and Sera | p. 295 |
| Amino Acid Metabolism of a High Density Perfusion Culture | p. 301 |
| Kinetics of Cell Metabolism and Antibody Production in High Concentration Perfusion Cultures | p. 309 |
| Growth Yields of Hybridoma Cells and Monoclonal Antibody Production in High Density Culture | p. 325 |
| Towards a Strategy for High Density Cultures of Vero Cells in Stirred Tank Reactors | p. 335 |
| 50L Scale Perfusion Culture of Hybridoma Cells by Gravitational Settling for Cell Separation | p. 341 |
| Production of Monoclonal Antibodies with a Radial-Flow Bioreactor | p. 347 |
| Factors Affecting the Yield of Baculovirus Insect Cell System by Hollow-Fiber Culture | p. 355 |
| High-Density Animal Cell Culture by Gas Sparging | p. 361 |
| Non-Woven Fabrics for Immobilizing Mammalian Cells | p. 369 |
| Statistical Design of Culture Medium for Recombinant Interferon-[gamma] Production | p. 375 |
| Medium Optimization for Perfused Culture to Provide High Product Titer | p. 383 |
| eRDF Medium Enhances Antibody Production of IgG and IgM Secreting Hybridomas | p. 391 |
| Serum-Free Media for Large-Scale Suspension Cultures | p. 397 |
| Suspension Culture of Mouse Hybridoma HB8852 Cells with a Protein-Free Medium | p. 403 |
| Improved Monoclonal Antibody Production via Controlled Feeding Strategies During Fed-batch Cultures of a Hybridoma Cell Line Utilizing Protein Free Media | p. 409 |
| Prediction of Disruption of Animal Cells by Laminar and Turbulent Flows | p. 417 |
| Fed-Batch Propagation of Mouse Hybridoma and Human Lymphoblastoid Cell Lines (LCLs) | p. 425 |
| Bioreactor with a Radial-Flow Non-Woven Fabric Bed for Animal Cell Culture | p. 433 |
| Partial Cell Culture Medium Recirculation Experience in Pilot Scale | p. 443 |
| Adaptation to Stirred Culture - A Study of a Moderately Shear Sensitive Cell Line (PQXB1/2) | p. 447 |
| Evaluation of Optimal Process Parameters for the Membrane Dialysis Bioreactor with Integrated Radial-Flow Fixed Bed | p. 455 |
| High Cell Density Perfusion Culture of Hybridoma Cells for Production of Monoclonal Antibodies in the Celligen Packed Bed Reactor | p. 463 |
| Metabolic Parameters of a Hybridoma Cell Line in Batch and Continuous Cultivation | p. 471 |
| Development of a New Disposable Culture System for Human Lymphokine-Activated Killer (LAK) Cells | p. 479 |
| New Method for Observing Cells Inside a Macroporous Microcarrier | p. 487 |
| Production of an [alpha]-Amidating Enzyme ([alpha]-AE) in Recombinant CHO Cells | p. 493 |
| Development of Instrumentation and Control Strategy in Bioreactor Culture of Hybridoma Cells | p. 501 |
| Effect of Dissolved Oxygen Concentration on Growth of Mouse-Mouse Hybridoma | p. 509 |
| Isolation of Autocrine Growth Factors Producing Mouse Hybridoma Cell Lines | p. 515 |
| Production of Multisubunit Particles for Use as Vaccines Using the Baculovirus Expression Vector System (BEVS) | p. 521 |
| Spontaneous Apoptosis in Mouse Hybridoma Culture | p. 529 |
| Cell Cycle Dynamics of Antibody Formation in Hybridomas | p. 535 |
| Effect of the Cell-Cycle Phase on Hybridoma Culture | p. 543 |
| Physiological Aspects of Scaling Up and Monitoring | p. 551 |
| A Comparative Study of the Immunopotentiating of Adjuvant Formulations Containing Glycopeptides | p. 557 |
| Establishment and Characterization of Monoclonal Antibodies Against Fish Virus (Iridoviridae) | p. 565 |
| The Production of Recombinant Antibodies Using the Glutamine Synthetase (GS) System | p. 573 |
| Generation of Supranatural Antibodies by Modifying the L Chains: Cell Hybridization and Glycotechnology | p. 579 |
| Two-Stage Chemostat Studies of Hybridoma Growth, Nutrient Utilisation, and Monoclonal Antibody Production | p. 585 |
| The Use of Artificial Intelligence to Enhance the Accuracy of Hybridoma Growth and Metabolism | p. 595 |
| Immunoglobulin Production Stimulating Factor (IPSF) Derived from Namalwa Cells | p. 601 |
| One-Step Purification of F(ab')[subscript 2] Fragments of Mouse Monoclonal Antibodies (Immunoglobulins G[subscript 1] and M) by Hydrophobic Interaction HPLC | p. 609 |
| Application of Anti-Tetanus Human Monoclonal Antibodies | p. 617 |
| Genetically Engineered Antibodies | p. 625 |
| Applications of Human Monoclonal Antibodies to Various Clinical Uses | p. 641 |
| Reactivity of Human Monoclonal Antibody BD9-D12 to Cancer Cells and Tissues | p. 647 |
| Cell Culture in Europe: A Review of Today's Market for Cell Culture Products and Services | p. 653 |
| Author Index | p. 661 |
| Subject Index | p. 665 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
