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Angiogenesis in Brain Tumors : Cancer Treatment and Research - Matthias Kirsch

Angiogenesis in Brain Tumors

Cancer Treatment and Research

By: Matthias Kirsch (Editor), Peter McL. Black (Editor)

Hardcover Published: 29th February 2004
ISBN: 9781402077043
Number Of Pages: 358

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The mutual relationship between tumor growth and concomitant neovascularization offers important insight into the biology of brain tumors and the development of new treatment strategies. Many of the early findings in the biology of angiogenesis have been investigated using brain tumor models. Angiogenesis in Brain Tumors is part of the "Cancer Treatment and Research" book series and this volume provides an overview of the biology of angiogenesis in the central nervous system, the role of angiogenesis in brain tumor development and growth, and therapeutic applications including clinical trials. 'Angiogenesis is a critical component of tumor growth. This text evaluates the role of neovascularization in brain tumor development and growth, and presents therapeutic applications including clinical trials. Distinguished investigators in the field discuss the critical signaling cascades that affect angiogenesis and evaluate strategies that inhibit the process that may provide therapeutic benefit against these devastating cancers.' Steven T. Rosen, M.D., Series Editor

Contributing Authorsp. vii
Principles of Angiogenesis in the Central Nervous Systemp. 1
Vasculogenesis and Angiogenesisp. 3
Morphogenesis of Embryonic CNS Vesselsp. 33
Mathematical Modeling of Tumour-Induced Angiogenesis: Network Growth and Structurep. 51
Assessment of Angiogenesis in Neuro-Oncologyp. 77
Histologic Measures of Angiogenesis in Human Primary Brain Tumorsp. 79
Angiogenesis in Transgenic Models of Multistep Angiogenesisp. 97
Models for Angiogenesis in Gliomasp. 115
Protocol for Isolation of HCECp. 137
Protocol for MRI Monitoring of Orthotopic Glioma Growth in the Rat Brainp. 139
Methods to Study Angiogenesis in vitrop. 141
The Rabbit Corneal Pocket Assay for the Study of Angiogenesisp. 147
Brain Tumor Related Angiogenesisp. 153
Role of Nitric Oxide in Tumor Angiogenesisp. 155
Angiogenesis-related Growth Factors in Brain Tumorsp. 169
Role of VEGF in Developmental Angiogenesis and in Tumor Angiogenesis in the Brainp. 191
Hypoxia and Hypoxia Inducible Factors (HIF) as Important Regulators of Tumor Physiologyp. 219
Vascular Microenvironment in Gliomasp. 249
Angiogenesis and Invasion in Gliomasp. 263
Metastasis and Angiogenesisp. 285
Clinical Application in Neuro-Oncologyp. 305
Inhibition of Angiogenesis as a Therapeutic Strategy Against Brain Tumorsp. 307
Anti-Angiogenic Chemotherapy in Central Nervous System Tumorsp. 337
Indexp. 351
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9781402077043
ISBN-10: 1402077041
Series: Cancer Treatment and Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 358
Published: 29th February 2004
Country of Publication: US
Dimensions (cm): 24.08 x 16.66  x 2.59
Weight (kg): 0.76