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An Introduction to Medicinal Chemistry - Graham Patrick

An Introduction to Medicinal Chemistry

Paperback Published: 29th May 2017
ISBN: 9780198749691
Number Of Pages: 832

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For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?

An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development.

The Online Resource Centre features:

For students:
DT Multiple Choice Questions to support self-directed learning
DT Web articles describing recent developments in the field and further information on topics covered in the book
DT Journal Club to encourage students to critically analyse the research literature
DT Molecular Modelling Exercises, with new exercises in Chem3D
DT New assignments to help students develop data analysis and problem solving skills

For registered adopters of the book:

DT A test bank of additional multiple-choice questions, with links to relevant sections in the book
DT Answers to end-of-chapter questions.
DT Figures from the book, ready to download.
DT Power Point slides to accompany every chapter in the book.

Industry Reviews

`It is by far the best book on the market for medicinal chemistry and drug discovery.' Professor Steven Bull, University of Bath `Summarizes the chemistry of medicinal agents in a manner that easily facilitates understanding of the core principles in the context of pharmacological drug action and clinical therapeutics.' Professor John Marriott, University of Birmingham

1: Drugs and drug targets - an overview Part A Drug targets - structure and function 2: Protein structure and function 3: Enzymes: structure and function 4: Receptors: structure and function 5: Receptors and signal transduction 6: Nucleic acids: structure and function Part B Pharmacodynamics and pharmacokinetics 7: Enzymes as drug targets 8: Receptors as drug targets 9: Nucleic acids as drug targets 10: Miscellaneous drug targets 11: Pharmacokinetics and related topics Case study 1: Statins Part C Drug discovery, design, and development 12: Drug discovery: finding a lead 13: Drug design: optimizing target interactions 14: Drug design: optimizing access to the target 15: Getting the drug to market Case study 2: The design of ACE inhibitors Case study 3: Artemisinin and related antimalarial drugs Case study 4: The design of oxamniquine Part D Tools of the trade 16: Combinatorial synthesis 17: Computers in medicinal chemistry 18: Quantitative structure-activity relationships (QSAR) Case study 5: De novo design of a thymidylate synthase inhibitor Part E Selected topics in medicinal chemistry 19: Antibacterial agents 20: Antiviral agents 21: Anticancer agents 22: Cholinergics, anticholinergics, and anticholinesterases 23: Drugs acting on the adrenergic nervous system 24: Opioid analgesics 25: Antiulcer agents 26: Cardiovascular drugs Case study 6: Steroidal anti-inflammatory agents Case Study 7: Design of a novel antidepressant Case Study 8: The design and development of aliskiren Case Study 9: Factor Xa inhibitors Case Study 10: Reversible inhibitors of HCV NS3-4A protease Appendices

ISBN: 9780198749691
ISBN-10: 0198749694
Audience: Tertiary; University or College
Format: Paperback
Language: English
Number Of Pages: 832
Published: 29th May 2017
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 19.05 x 25.4  x 2.54
Weight (kg): 1.7
Edition Number: 6
Edition Type: Revised

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