Comprises over two dozen articles dealing with the various aspects of and the recent findings on aluminum accumulation and toxicity. Presents a fundamental approach to the chemistry of the problem, and discusses the determination and metabolism of aluminum and the pathophysiological mechanisms of th
` ... the material presented provides valuable information concerning the biological effects and clinical syndromes associated with aluminum exposure. This volume should be useful for students and nephrologists who are interested in furthering their understanding of the area.'
Dialysis and Transplantation, 20/1, January 1991
General.- Historical survey of aluminum-related diseases.- Chemistry of aluminum.- The metabolism of aluminum.- Intestinal absorption of aluminum.- Aluminum determination in biological samples.- Quality control of aluminum measurements.- Pathophysiology.- Pathophysiologic mechanisms of aluminum toxicity: Aluminum-induced bone disease.- Aluminum encephalopathy: Experimental vs human.- Alzheimer's disease: Aluminum and fibrinous proteins.- Aluminum interaction with macromolecules and membranes.- Cellular and subcellular localization of aluminum: Histochemistry.- Cellular and subcellular localization of aluminum.- Experimental models of aluminum toxicity.- Clinical.- Sources of aluminum.- Unusual sources of aluminum.- Experimental aluminum induced bone disease.- Aluminum induced bone disease: Clinical features.- Aluminum induced bone disease: Histology.- Dialysis encephalopathy.- Other clinical syndromes associated with aluminum. Microcytic anemia, joint pain, severe infections, liver dysfunction.- Aluminum toxicity in childhood.- Occupational exposure to aluminum and its compounds and their health effects.- Diagnosis.- The Diagnosis of aluminum toxicity.- Treatment.- Deferoxamine therapy of aluminum toxicity in dialysis patients.- Alternative phosphate binders for aluminum hydroxide.- Risk factors for aluminum toxicity and its prevention.- Index of subjects.
Series: Developments in Cardiovascular Medicine
Number Of Pages: 378
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6
Weight (kg): 0.73