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Alkaloids Vol 60 : Chemistry and Biology - Geoffrey A. Cordell

Alkaloids Vol 60

Chemistry and Biology

Hardcover

Published: 1st October 2003
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This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than forty years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.
Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective.
Comprehensive dynamic reviews written by the leading authors in the respective fields.
Broader coverage than before on the biological aspects.

Contributorsp. vii
Prefacep. ix
Clinical Studies of Camptothecin and Derivatives
Introductionp. 1
Mechanisms of Actionp. 3
Mutagenicity and Resistance Mechanismsp. 7
Irinotecanp. 9
Topotecanp. 19
Considerations of Route of Administrationp. 27
Investigational Derivativesp. 29
Conclusionsp. 33
Referencesp. 35
Tremorgenic and Nontremorgenic 2,3-Fused Indole Diterpenoids
Introductionp. 51
Isolationp. 53
Synthesisp. 125
Biosynthesisp. 144
Structure and Tremorgenicityp. 155
Referencesp. 158
The Daphniphyllum Alkaloids
Introductionp. 165
Structures of Representative Alkaloidsp. 170
Biosynthesis and Biogenesisp. 184
Synthesisp. 193
Conclusionsp. 202
Referencesp. 203
The Manzamine Alkaloids
Introductionp. 207
Isolation and Structure Elucidation from Marine Spongesp. 214
Biogenesis and Biosynthesisp. 223
Synthesisp. 264
Pharmacologyp. 270
Conclusionsp. 277
Referencesp. 278
Sesquiterpene Pyridine Alkaloids
Introductionp. 287
Evoninate Sesquiterpene Pyridine Alkaloids and Derivativesp. 289
Wilfordate Sesquiterpene Pyridine Alkaloids and Derivativesp. 307
Edulinate Sesquiterpene Pyridine Alkaloidsp. 315
Cassinate Sesquiterpene Pyridine Alkaloidsp. 317
Lower Molecular Weight Sesquiterpene Pyridine Alkaloidsp. 317
Non-Celastraceous Sesquiterpene Pyridine Alkaloidsp. 318
Biosynthesis and Biogenesisp. 322
Biological Activityp. 330
Taxonomic Considerationsp. 334
Synthesisp. 334
Referencesp. 339
Chemical and Biological Aspects of Melanin
Introductionp. 345
Biogenesis of Melaninp. 347
Natural Melaninsp. 354
Investigations of Melanins by Physical Methodsp. 373
Synthetic Melaninsp. 376
Physicochemical Properties and Biological Functions of Melaninsp. 379
Referencesp. 384
Indexp. 393
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780124695603
ISBN-10: 0124695604
Series: The Alkaloids : Book 60
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 414
Published: 1st October 2003
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 15.2 x 22.9  x 1.91
Weight (kg): 0.78