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Airway Mucus : Basic Mechanisms and Clinical Perspectives :  Basic Mechanisms and Clinical Perspectives - D. F. Rogers

Airway Mucus : Basic Mechanisms and Clinical Perspectives

Basic Mechanisms and Clinical Perspectives

By: D. F. Rogers (Editor), Mike Lethem (Editor)

Hardcover Published: September 1997
ISBN: 9783764356910
Number Of Pages: 388

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Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.

List of Contributors
Preface
Airway Surface Liquid: Concepts and Measurementsp. 1
Structure and Biochemistry of Human Respiratory Mucinsp. 19
Airway Mucin Genes and Gene Productsp. 41
The Microanatomy of Airway Mucus Secretionp. 67
Mechanisms Controlling Airway Ciliary Activityp. 91
Rheological Properties and Hydration of Airway Mucusp. 117
Goblet Cells: Physiology and Pharmacologyp. 149
Airway Submucosal Glands: Physiology and Pharmacologyp. 179
Mucus-Bacteria Interactionsp. 211
Experimental Induction of Goblet Cell Hyperplasia In Vivop. 227
Mucus Hypersecretion and Its Role in the Airway Obstruction of Asthma and Chronic Obstructive Pulmonary Diseasep. 275
Mucus and Airway Epithelium Alterations in Cystic Fibrosisp. 301
Drug-Mucus Interactionsp. 327
Therapeutic Approaches to the Lung Problems in Cystic Fibrosisp. 341
Therapeutic Approaches to Airway Mucous Hypersecretionp. 365
Indexp. 385
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783764356910
ISBN-10: 376435691X
Series: Respiratory Pharmacology and Pharmacotherapy
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 388
Published: September 1997
Publisher: Birkhauser Verlag AG
Country of Publication: CH
Dimensions (cm): 23.5 x 15.5  x 2.39
Weight (kg): 0.84