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Aging at the Molecular Level : Biology of Aging and its Modulation - Thomas von Zglinicki

Aging at the Molecular Level

Biology of Aging and its Modulation

By: Thomas von Zglinicki (Editor)

Hardcover Published: 1st November 2003
ISBN: 9781402017384
Number Of Pages: 248

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During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation.
Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

From the reviews:

"This volume is the first in a series of five in which the biology of ageing will be explored. ... Altogether, this is a fairly comprehensive coverage of the current themes at the molecular level, with the further areas to be explored being well highlighted. The chapters are well-referenced and this timely text will be especially useful to those workers entering the field." (P.B.Gahan, Cell Biochemistry & Function, Vol. 23 (5), 2005)

Editorial: About the series "Biology of aging and its modulation"p. vii
Prefacep. ix
Free radical production and antioxidant defense: a primerp. 1
Oxidative DNA damage and repair--implications for agingp. 11
Oxidative damage to proteinsp. 27
Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studiesp. 47
Genomic instability in human premature agingp. 65
Oxidative damage, somatic mutations and cellular agingp. 79
Mitochondria and agingp. 91
Biological clocks in the aging cellp. 107
Telomeric damage in agingp. 121
Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic micep. 131
Non-oxidative modification of DNA and proteinsp. 145
Transcriptional and translational dysregulation during agingp. 179
Metabolic regulation of gene silencing and life spanp. 193
The proteasome in agingp. 213
Aging and lysosomal degradation of cellular constituentsp. 233
Indexp. 243
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9781402017384
ISBN-10: 1402017383
Series: Biology of Aging and its Modulation
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 248
Published: 1st November 2003
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 1.91
Weight (kg): 0.68