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Advances in Systems Biology : Advances in Experimental Medicine and Biology - Lee K. Opresko

Advances in Systems Biology

Advances in Experimental Medicine and Biology

By: Lee K. Opresko (Editor), Julie M. Gephart (Editor), Michaela B. Mann (Editor)

Hardcover Published: 19th May 2004
ISBN: 9780306483141
Number Of Pages: 108

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This book is based on the proceedings of the inaugural symposium "Northwest Symposium for Systems Biology." Particular focus is on identifying current breakthrough technologies and their application to important model systems. By integrating computational sciences, high-throughput technologies and quantitative biology, this book will advance the understanding of not just the function of individual genes, proteins and smaller molecules like hormones, but also how all of these molecules interact within a cell.
This volume will be a collection of presentations on four topics that comprise the scope of the Genomes to Life project recently announced by the Department of Energy. They are four aspects of a system biology approach to understanding microbial communities. These topics include complex microbial systems, gene regulatory networks, molecular machines/ multiprotein complexes and computational techniques. The range of material covered will include the following:
-Molecular biological methods for the analysis of complex microbial communities and the use of specific bacterial species for bioremediation,
-The study of gene regulation through the use of genomics as well as specific regulation in bacteria (by methylation) and in yeast (via signal transduction pathways),
-Structure and function of multiprotein complexes involved in protein degradation, muscle function and protein kinase attachments in cells,
-Computational approaches to the analysis of large data sets to yield useful information.

Introduction : about the northwest symposium for systems biologyp. 1
Complex microbial systems
High-throughput techniques for analyzing complex bacterial communitiesp. 5
Computational methods
A systems approach to discovering signaling and regulatory pathways - or how to digest large interaction networks into relevant piecesp. 21
Genome function - a virus-world viewp. 31
Molecular machines : multiprotein complexes
Intracellular proteolysis and proteasomesp. 49
Conformational switching in musclep. 61
Gene regulatory networks
The intricate workings of a bacterial epigenetic switchp. 83
Yeast signal transduction : regulation and interface with cell biologyp. 91
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306483141
ISBN-10: 0306483149
Series: Advances in Experimental Medicine and Biology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 108
Published: 19th May 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 1.27
Weight (kg): 1.1