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Advances in Protein Chemistry Vol 64 : Volume 64 - Wah Chiu

Advances in Protein Chemistry Vol 64

Volume 64

Hardcover Published: 25th August 2003
ISBN: 9780120342648
Number Of Pages: 543

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This volume covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses.
* Covers viral assembly using heterologous expression systems and cell extracts
* Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment
* Includes information on structural studies on antibody/virus complexes

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PRAISE FOR THE SERIES "The authority, originality, and editing of the reviews are first class." -NATURE "The Advances in Protein Chemistry series has been a major factor in the education of protein chemists." -JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prefacep. xi
Viral Assembly Using Heterologous Expression Systems and Cell Extracts
Introductionp. 1
The Driving Force behind the Development of Heterologous Expression Systems for the Study of Viral Assembly and Structurep. 2
Diversity of Heterologous Expression Systemsp. 4
Guidelines for Choosing a Heterologous Expression Systemp. 16
Representative Examples of Viral Assembly in Heterologous Expression Systemsp. 20
Conclusionsp. 32
Referencesp. 32
Hybrid Vigor: Hybrid Methods in Viral Structure Determination
Introductionp. 37
Techniquesp. 38
Hybridsp. 56
Conclusionp. 83
Referencesp. 83
Determination of Icosahedral Virus Structures by Electron Cryomicroscopy at Subnanometer Resolution
Introductionp. 93
Electron Cryomicroscopyp. 94
Overview of Methods for Subnanometer-resolution Reconstructionsp. 101
Example of Data Collection, Evaluation, and Processingp. 105
Visualization and Structure Interpretationp. 117
Conclusionp. 122
Referencesp. 122
Structural Folds of Viral Proteins
Introductionp. 125
Terminologyp. 126
Virus Familiesp. 126
Determination of Structural Foldp. 126
Prototypical Viral Foldsp. 128
Survey Through the Virus Familiesp. 132
Common Themesp. 184
Phylogenetic Relationshipsp. 185
Referencesp. 187
Virus Particle Dynamics
Introductionp. 197
Particle Fluctuations and Infectivityp. 199
Large-Scale Reversible Quaternary Structure Changes in Virusesp. 203
Large-Scale Irreversible Quaternary Structure Changes in Double-Stranded DNA Bacteriophagep. 209
Conclusionsp. 216
Referencesp. 216
Viral Genome Organization
Introductionp. 219
Single-Stranded RNA Virusesp. 221
Double-Stranded RNA Virusesp. 229
Single-Stranded DNA Virusesp. 235
Double-Stranded DNA Virusesp. 240
Conclusionsp. 246
Referencesp. 248
Mechanism of Scaffolding-Assisted Viral Assembly
Introductionp. 259
[phi]X174 Morphogenesisp. 261
Prescaffolding Stages: Coat Proteins and Chaperonesp. 261
The [phi]X174 Internal Scaffolding Proteinp. 263
Genetic Data for Scaffolding Protein Flexibility: [phi]X174 and Herpesviridaep. 264
Structural Data for Scaffolding Protein Flexibility: [phi]X174, P22, and Herpesviridaep. 266
So What's All This Fuss over These C Termini?p. 267
Internal Scaffolding Protein Function in One and Two Scaffolding Protein Systems: [phi]X174 versus P22 and Herpesvirusesp. 269
The Assembly Pathway of Bacteriophage P22p. 270
The Role of the P22 Scaffolding Proteinp. 272
Functional Domains of the P22 Scaffolding Proteinp. 274
Physical Chemistry of the P22 Scaffolding Proteinp. 280
The Mechanism of Scaffolding-Assisted Assemblyp. 281
External Scaffolding Proteinsp. 283
The [phi]X174 External Scaffolding Proteinp. 284
P4 Sid Proteinp. 290
Herpesvirus Triplex Proteinsp. 292
Scaffolding-Like Functionsp. 293
Referencesp. 295
Molecular Mechanisms in Bacteriophage T7 Procapsid Assembly, Maturation, and DNA Containment
Introductionp. 301
Overexpressed T7 and T3 Connectors have 12- and 13-Fold Symmetryp. 303
The Procapsid Core has 8-Fold Symmetry: Another Symmetry Mismatchp. 303
Procapsid Structurep. 305
Procapsid Maturation: Expansion is Initiated in the Connectorp. 308
Packaging and Parting of DNAp. 309
The Mature Capsid Structure: Filled and Empty Shellsp. 310
Structure of Packaged DNAp. 315
Summaryp. 319
Referencesp. 320
Conformational Changes in Enveloped Virus Surface Proteins During Cell Entry
Introduction: Multiple Stops on the Protein-Folding Landscapep. 325
Influenza Hemagglutininp. 326
Retrovirusesp. 338
Paramyxoviruses Turn Paradigms Upside Down?p. 350
Oligomerization State Switches in Flaviviruses and Alphavirusesp. 353
Concluding Remarksp. 356
Referencesp. 357
Enveloped Viruses
Introductionp. 363
General Structural Features of Enveloped Virusesp. 364
Alphavirus Structurep. 365
Flavivirus Structurep. 367
Virus Assemblyp. 369
Virus-Cell Fusionp. 372
Concluding Remarksp. 373
Referencesp. 374
Studying Large Viruses
What is a Large Virus?p. 379
Why Large Viruses?p. 381
Why Study Large Viruses?p. 384
Methods of Structural Analysisp. 385
Complexity of Organizationp. 386
Structural Foldsp. 393
Assembly Mechanismsp. 394
Maturationp. 399
Accessory Proteinsp. 400
Packagingp. 401
Future Prospectsp. 402
Summaryp. 403
Referencesp. 404
Structural Studies on Antibody-Virus Complexes
Introductionp. 409
Backgroundp. 410
Structural Studies on Virus-Antibody Complexesp. 412
Conclusionsp. 439
Referencesp. 443
Structural Basis of Nonenveloped Virus Cell Entry
Introductionp. 455
Reovirus Cell Entry, Tissue Tropism, and Pathogenesisp. 456
Reovirus Structurep. 458
Proteolysis of the [sigma]1 Protein Regulates Viral Growth in the Intestine and Systemic Spreadp. 460
The [sigma]1 Tail Binds Cell Surface Sialic Acidp. 462
The [sigma]1 Head Binds Junctional Adhesion Moleculep. 463
Reovirus-Receptor Interactions Promote Cell Death by Apoptosisp. 464
Picornavirus-Receptor Complexesp. 465
Poliovirus Cell Entry Mechanismsp. 466
Identification of the Poliovirus Attachment Receptorp. 468
Poliovirus-Associated Lipid Moleculesp. 469
Receptors for Rhinovirusesp. 470
Receptors for Other Picornavirusesp. 473
Human Adenovirusesp. 475
Adenovirus Attachment Receptorsp. 476
Cell Integrins Promote Adenovirus Internalizationp. 478
Signaling Events Associated with Adenovirus Internalizationp. 481
[alpha subscript v] Integrins Regulate Adenovirus-Mediated Endosome Disruptionp. 482
Conclusionsp. 482
Referencesp. 484
Author Indexp. 493
Subject Indexp. 531
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780120342648
ISBN-10: 0120342642
Series: Advances in Protein Chemistry : Book 64
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 543
Published: 25th August 2003
Publisher: ACADEMIC PR INC
Country of Publication: US
Dimensions (cm): 22.0 x 17.22  x 2.85
Weight (kg): 0.97

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