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Advances in Immunology, Volume 92 : Volume 92 - Frederick W. Alt

Advances in Immunology, Volume 92

Volume 92

Hardcover Published: 6th November 2006
ISBN: 9780123736369
Number Of Pages: 344

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Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Contributorsp. ix
Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease
Abstractp. 1
Introductionp. 2
Immunological Alterations in SLEp. 5
Genetics of SLE Susceptibility in Humansp. 22
Murine Models of SLEp. 28
Modeling Disease Developmentp. 40
Referencesp. 45
Avian Models with Spontaneous Autoimmune Diseases
Abstractp. 71
Introductionp. 72
Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disordersp. 75
The OS Chicken: Model for Human Hashimoto Diseasep. 83
The UCD-200 Line of Chickens: A Model for Human Systemic Sclerosisp. 92
The SL Chicken Model for Human Autoimmune Vitiligop. 102
Conclusions and Outlookp. 108
Referencesp. 108
Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity
Abstractp. 119
Introductionp. 120
Phenotype of CD4[superscript +]CD25[superscript +] nTreg Cellsp. 122
Factors Regulating the Expansion and Specificity of nTreg Cellsp. 126
Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cellsp. 129
Growth Factor-Mediated Control of nTreg Cell Development, Function, and Homeostasisp. 134
Control of Autoimmune Responses by nTreg Cellsp. 138
Summary and Conclusionsp. 145
Referencesp. 146
BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation
Abstractp. 157
Overview of BTLA and HVEM Ligand Discoveryp. 158
Structural Characterization of BTLA Bound to HVEMp. 164
Viral Modulators of the HVEM-BTLA Pathwayp. 164
Expression and Regulation of BTLA, LIGHT, and HVEM on T Cells and APCsp. 165
Mechanisms of the CD28 Family Inhibitory Receptorsp. 167
Consequences of HVEM Ligationp. 173
BTLA and HVEM in Models of Diseasep. 176
Conclusionsp. 178
Referencesp. 179
The Human T Cell Response to Melanoma Antigens
Abstractp. 187
Introductionp. 188
Melanoma Antigensp. 188
Measurement of Antigen-Specific T Cell Responsesp. 190
Naturally Acquired Tumor Antigen-Specific T Cell Responsesp. 196
Vaccine-Induced T Cell Responsesp. 202
Regulation of Tumor Antigen-Specific T Cell Responsesp. 206
Conclusionsp. 207
Referencesp. 209
Antigen Presentation and the Ubiquitin-Proteasome System in Host-Pathogen Interactions
Abstractp. 226
Host-Pathogen Interactionsp. 227
Manipulation of the Host Response by Pathogens: Some General Considerationsp. 229
Antigen Presentationp. 230
Class I MHC Antigen Presentationp. 230
Pathogen Recognition by CD8[superscript +] T Cells and NK Cellsp. 232
Class II MHC Antigen Presentationp. 233
Ubiquitin-Proteasome Systemp. 234
The Ubiquitin Conjugation Cascadep. 234
Ubiquitin Ligasesp. 236
Ubiquitin Chains and Ubiquitin-Like Modifiers (Ubls)p. 237
Deubiquitinating Enzymesp. 239
The Proteasomep. 239
ER Quality Control and Degradationp. 240
ERAD Substrate Recognitionp. 241
ERAD E3 Ligasesp. 243
Mammalian ERAD E3sp. 244
The Elusive Disloconp. 247
Driving Dislocation and the Ub-Binding Route to the Proteasomep. 247
Peptide N-Glycanasep. 249
Viral Interference with Class I MHC Antigen Presentationp. 250
Human Cytomegalovirusp. 251
HCMV Interference with Class I MHC Antigen Presentationp. 251
Dislocation from the ER: HCMV US11 and US2p. 254
Signal Peptide Peptidase Is Required for Dislocation from the ERp. 255
SPP and Generation of HLA-E Epitopesp. 256
SPP and Processing of the Hepatitis C Virus Core Proteinp. 256
SPP and Calmodulin Signalingp. 257
SPP Peptide Peptidase and Developmentp. 257
SPP and ER Quality Controlp. 258
Three Routes of Pathogen-Mediated ER Protein Disposalp. 261
Pathogen Interference with Class II MHC Antigen Presentationp. 264
Inhibition of Recognition at the Surface of the APCp. 264
Class II MHC Downregulation from the Surface of the APCp. 265
CD4 Downregulation from the Surface of the CD4[superscript +] T Cellp. 266
Pathogen Manipulation of the Ubiquitin-Proteasome Systemp. 269
Interference with Proteasomal Proteolysisp. 270
Control of Infectionp. 271
Virus Buddingp. 272
Bacterial Chromosome Integrationp. 273
ISGylation and deISGylationp. 274
Control of Inflammationp. 275
Posttranscriptional Gene Silencingp. 275
Downregulation of Cell Surface Receptors by Pathogen-Encoded E3sp. 276
Programmed Cell Death in Plantsp. 277
Cytokine Responsesp. 277
Pathogen-Encoded DUBsp. 278
Conclusions and Future Directionsp. 280
Referencesp. 280
Indexp. 307
Contents of Recent Volumesp. 325
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780123736369
ISBN-10: 0123736366
Series: Advances in Immunology : Book 92
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 344
Published: 6th November 2006
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 22.9 x 15.2  x 2.54
Weight (kg): 0.78
Edition Number: 92