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Advances in Experimental Medicine and Biology

By: Robert Dantzer (Editor), Emmanuelle E. Wollmann (Editor), Raz Yirmiya (Editor)

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Hardcover | 31 July 1999

At a Glance

Hardcover
352 Pages

Dimensions(cm)
23.39 x 15.6 x 2.06

Hardcover

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Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Immunology Other Branches of Medicine Clinical Psychology Psychology Abnormal Psychology Neurology & Clinical Neurophysiology Physiological & Neuro-Psychology, Biopsychology Pharmacology

Science Biology, Life Sciences Life Sciences in General Neurosciences

Depression and Immunity
Immune Correlates of Depression	p. 1
Major Depression and Activation of the Inflammatory Response System	p. 25
Cytokine Production in Depressed Patients	p. 47
Indicators of Immune Activation in Depressed Patients	p. 59
Brain Effects of Cytokines
Mood and Cognitive Disorders in Cancer Patients Receiving Cytokine Therapy	p. 75
Mechanisms of the Behavioural Effects of Cytokines Robert Dantzer, Arnaud Aubert, Rose-Marie Bluthe, Gilles Gheusi	p. 83
Effects of Cytokines on Glucocorticoid Receptor Expression and Function: Glucocorticoid Resistance and Relevance to Depression	p. 107
Effects of Cytokines on Cerebral Neurotransmission: Comparison with the Effects of Stress	p. 117
Inflammation and Brain Function under Basal Conditions and during Long-Term Elevation of Brain Corticotropin-Releasing Hormone Levels	p. 129
Effects of Stress on Cytokine Production and Actions
Dynamic Regulation of Proinflammatory Cytokines	p. 153
Cross-Sensitization between Immune and Non-Immune Stressors: A Role in the Etiology of Depression?	p. 179
Effects of Cytokines and Cytokine Antagonists in Animal Models of Depression
Anhedonic and Anxiogenic Effects of Cytokine Exposure	p. 199
Stress, Learned Helplessness, and Brain Interleukin-1[beta]	p. 235
Stress, Depression, and the Role of Cytokines	p. 251
Effects of Antidepressants on Cytokine Production and Action
Is There Evidence for an Effect of Antidepressant Drugs on Immune Function?	p. 267
Cytokines, "Depression Due to a General Medical Condition," and Antidepressant Drugs	p. 283
Cytokines, Stress, and Depression: Conclusions and Perspectives	p. 317
Contributors	p. 331
Index	p. 335
Table of Contents provided by Syndetics. All Rights Reserved.

Advances in Experimental Medicine and Biology

At a Glance

Hardcover

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