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Advances in Enzyme Regulation, Volume 43 : Volume 43 - G. Weber

Advances in Enzyme Regulation, Volume 43

Volume 43

By: G. Weber

Hardcover Published: 10th July 2003
ISBN: 9780080442945
Number Of Pages: 486

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This volume contains papers of 23 outstanding scientists who are working at the leading edge of metabolic regulation studies. Much of the volume focuses on novel aspects of signal transduction with emphasis on the role of phospholipase C in cell control mechanisms.


One of the highlights of this volume is always the Special Symposium Lecture. This lecture was given for fifteen years by Nobel laureate, Sir Hans A. Krebs (UK) (now deceased). This year the Lecture was given by Nadir Maraldi, Director of the Laboratory of Cellular Biology and Electron Microscopy, University of Bologna, Italy. Professor Maraldi's presentation is on the important and novel subject of "Nuclear Proteins and Human Disease."

Acknowledgementsp. xv
List of Participantsp. xvii
Inositide Signaling
Re-examination of the Significance of Nuclear Localization of PLC[beta]1 in the Likelihood of its Involvement in Neoplastic Cell Growthp. 1
The Termination of PI3K Signalling by SHIP1 and SHIP2 Inositol 5-Phosphatasesp. 15
Drug Targeting and Resistance
Inhibitors of Diverse Metabolic Steps Cause Increased Apoptosis in Deoxyadenosine-Resistant Mouse Leukemia L1210 Cells That Lack p53 Expression: Convergence at Caspase-3 Activationp. 29
Targeting Signal Transductionp. 47
Tumor Metabolism
Utilization of the Promoter Region of the Midkine Gene as a Tool to Drive Therapeutic Genes in a Tumor Specific Mannerp. 57
Opportunities for Studying Cancer by Metabolomics: Preliminary Observations on Tumors Deficient in Hypoxia-Inducible Factor 1p. 67
Control of Phospholipase
Structural and Mechanistic Aspects of Phosphoinositide C[gamma] Regulationp. 77
Phospholipase C[delta]4: From Genome Structure to Physiological Functionp. 87
Activation of PI(4)P 5-Kinase by Small G Proteinsp. 107
Oxidative Stress
Importance of Phase 2 Gene Regulation in Protection against Electrophile and Reactive Oxygen Toxicity and Carcinogenesisp. 121
Ferritin Regulation by Oxidants and Chemopreventive Xenobioticsp. 135
Regulation of Gene Expression
The Regulation of Adipocyte Metabolism and Gene Expression by Interleukin-11p. 153
A Comprehensive Model for the Allosteric Regulation of Class Ia Ribonucleotide Reductasep. 167
Raf Kinases in Lung Tumor Developmentp. 183
Regulation of Cell Proliferation
Interaction of Cofilin with Serine Phosphatases PP1 and PP2A in Normal and Neoplastic Human T Lymphocytesp. 197
Regulation of Cell Survival by Atypical Protein Kinase C Isozymesp. 213
Translocation and Activation
Regulation of Cytosolic Phospholipase A[subscript 2] Translocationp. 229
On the Mechanism Coupling Phospholipase C[gamma]1 to the B- and T-Cell Antigen Receptorsp. 245
Evolutionary Analyses
Interpretive Proteomics--Finding Biological Meaning in Genome and Proteome Databasep. 271
Clostridum Perfringens Iota-Toxin, ADP-Ribosyltransferase: Structure and Mechanism of Actionp. 361
Signaling Pathway Interference
Dissection of Signal-Regulated Transcriptional Modules by Signaling Pathway Interference in Oncogene-Transformed Cellsp. 379
New Cysteine Protease Inhibitors in Physiological Secretory Fluids and their Medical Significancep. 393
Special Symposium Lecture
At the Nucleus of the Problem: Nuclear Proteins and Diseasep. 411
Author Indexp. 445
Subject Indexp. 457
Contents of Recent Volumesp. 467
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780080442945
ISBN-10: 0080442943
Series: Advances in Enzyme Regulation : Book 43
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 486
Published: 10th July 2003
Publisher: Elsevier Science & Technology
Country of Publication: GB
Dimensions (cm): 24.77 x 17.78  x 2.54
Weight (kg): 1.3

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