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Advances in Cancer Research : Volume 71 - George F. Vande Woude

Advances in Cancer Research

Volume 71

By: George F. Vande Woude (Editor), George Klein (Editor)

Hardcover Published: 1st April 1997
ISBN: 9780120066711
Number Of Pages: 385

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Volume 71 of Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to targets for improved cancer therapies. Kok "et all." Review the methodological advantages and limitations to localizing tumor suppressor genes, especially those on the short arm of chromosome 3. Peltomaki and de la Chapelle describe research on mismatch repair genes and their effects on colorectal cancer. McKenna and Cotter present findings on the functions and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B and how it controls and affects cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation frequencies of microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing levels of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects of HPV and the potential clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever review the studies that define HER-2/neu specific immunity in patients with cancer and the current vaccine strategies for generating specific immunity.

Praise for the Serial "This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." --AMERICAN SCIENTIST "Excellent, highly informative, in-depth reviews... expertly written, up-to-date, and well-referenced." --JOURNAL OF MEDICINAL CHEMISTRY

Foundations in Cancer Research: Fundamentals of Cancer Cell Biology
Introduction
Antecedents
Autobiographical Note
Foundations of Tissue Culture
Foundations of Cell Culture
Clones
The Immortals: Stable Cell Lines
The Mortals: Cell Strains
Food for Cells in Culture
Growth Factors
Short-Range Cell Interactions
Junctional Communication
Cell and Substrate Adhesion
The Tumor Viruses
Cell Fusion
Conclusion
References
The Step-by-Step Development of Epithelial Cancer: From Phenotype to Genotype
Cancer Development as Basic to Cancer Research
Patterns of Development of Epithelial Cancers
A Working Hypothesis
The Phenotypes
The Genotypes
The Challenge
References
Genetics of the Nevoid Basal Cell Carcinoma Syndrome
Introduction
Clinicopathological Features of NBCCS
Genetics of NBCCS
Strategies for Isolation of Candidate Genes
Discussion
References
Transforming Growth Factor-( System and Its Regulation by Members of the Steroid-Thyroid Hormone Superfamily
Introduction
Transforming Growth Factor-(. Dual Effects of TGF-(on Cell Proliferation
Regulation of Cell Differentiation by TGF-(. TGF-(in the Regulation of the Immune System
The Steroid-Thyroid Hormone Superfamily
Steroid Hormone Regulation of TGF-( Isoform Expression
Regulation of Plasminogen Activation by Steroids
Summary
References
c-Mycin the Control of Cell Proliferation and Embryonic Development
Introduction
The c-myc Gene
Structural and Functional Features of the c-Myc Protein
c-Myc as a Transcription Factor
c-Myc and Cell Proliferation
c-Myc in Embryonic Development
c-Myc and Differentiation
c-Myc and Apoptosis
References
Identification of the Genes Encoding Cancer Antigens: Implications for Cancer Immunotherapy
Introduction
Methodology
Human Melanoma Antigens Recognized by T Cells
Cancer Therapies Based on the Molecular Identification of Cancer Antigens
References
The MEN II Syndromes and the Role of the ret Proto-oncogene
Introduction
The MEN II Syndromes
The ret Proto-oncogene
Development of the Tissues Involved in MEN II, and Patterns of ret Expression
Speculations on How Different ret Mutations Result in the Associated Phenotypes and in Tumor Formation
Other Events in Tumor Progression
Animal Models of MEN II
Clinical Implications of the Identification of ret Mutations in MEN II
Future Prospects
References
Subject Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780120066711
ISBN-10: 0120066718
Series: Advances in Cancer Research : Book 71
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 385
Published: 1st April 1997
Publisher: ACADEMIC PR INC
Country of Publication: US
Dimensions (cm): 23.67 x 16.08  x 2.29
Weight (kg): 0.69